Financiado en parte por California Walnut Commission
Dietary walnut altered gene expressions related to tumor growth, survival, and metastasis in breast cancer patients: a pilot clinical trial
Hardman WE, Primerano DA, Legenza MT, Morgan J, Fan J, Denvir J
Nutrition research (New York, N.Y.) · 19 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- California Walnut Commission
- Gobierno
- National Institute of General Medical Sciences
- Gobierno
- West Virginia IDeA Networks of Biomedical Research Excellence
- Gobierno
- NIGMS NIH HHS
- Gobierno
- NIH/NIGMS
- Gobierno
- Marshall University COBRE, NIH/NIGMS
- Subvenciones
- National Institute of General Medical Sciences (U54-GM-104942); National Institute of General Medical Sciences (P20 GM121299); National Institute of General Medical Sciences (P20GM103434)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2019-03-10 · Nutr Res · vol. 66 · págs. 82–94
- Editorial
- Elsevier BV
- Citado
- 30 citas · más que el 91% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 61 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Nutrition, Genetics, and Disease
- Palabras clave
- walnut consumption, breast cancer, gene expression profiling, tumor growth, metastasis, apoptosis, cell proliferation, cell migration, cell adhesion, dietary intervention, RNA sequencing
- MeSH
- animals, humans, mice, juglans, nuts, breast neoplasms, neoplasm metastasis, rna, biopsy, needle, diet, pilot projects, gene expression regulation, neoplastic, middle aged, female, high-throughput nucleotide sequencing
6 autores
- W. Elaine Hardman🇺🇸 · autor de correspondenciaMarshall University
- Donald A. Primerano🇺🇸Marshall University
- Mary T. Legenza🇺🇸Edwards Comprehensive Cancer Center
- James Morgan
- Jun Fan🇺🇸Marshall University
- James Denvir🇺🇸Marshall University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Consumption of walnuts has slowed breast cancer growth and/or reduced the risk of mammary cancer in mice. The benefit against cancer was associated with altered expression of genes for cancer growth and survival. We hypothesized that walnut consumption would alter gene expression in pathologically confirmed breast cancers of women in a direction that would be expected to decrease breast cancer growth and survival, as was seen in mice. The study was a nonplacebo, 2-arm, clinical trial. Women with breast lumps large enough for research and pathology biopsies were recruited and randomized to walnut consuming or control groups. Immediately after biopsy collection, women in the walnut group began to consume 2 oz of walnuts per day until follow-up surgery. Pathological studies confirmed that lumps were breast cancer in all women who remained in the trial. At surgery, about 2 weeks after biopsy, additional specimens were taken from the breast cancers. Changes in gene expression in the surgical specimen compared to baseline were determined in each individual woman in walnut-consuming (n = 5) and control (n = 5) groups. RNA sequencing expression profiling revealed that expression of 456 identified genes was significantly changed in the tumor due to walnut consumption. Ingenuity Pathway Analysis showed activation of pathways that promote apoptosis and cell adhesion, and inhibition of pathways that promote cell proliferation and migration. These results support the hypothesis that, in humans, walnut consumption could suppress growth and survival of breast cancers.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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