Effects of photobiomodulation in the treatment of fractures: a systematic review and meta-analysis of randomized clinical trials
Neto FCJ, Martimbianco ALC, de Andrade RP, Bussadori SK, Mesquita-Ferrari RA, Fernandes KPS
Lasers in medical science · 22 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2019-04-13 · Lasers Med Sci · vol. 35 · número 3 · págs. 513–522
- Editorial
- Springer Science+Business Media
- Citado
- 32 citas · más que el 56% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 30 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Bone fractures and treatments · Biofield Effects and Biophysics
- Palabras clave
- low-level laser therapy, bone fractures, fracture healing, analgesia, physical function, radiographic healing, bone callus, inflammation, adverse events
- MeSH
- humans, fracture healing, fractures, bone, randomized controlled trials as topic, low-level light therapy
6 autores
- Frederico Carlos Jaña Neto🇧🇷Universidade Nove de Julho
- Ana Luiza Cabrera Martimbianco🇧🇷 · autor de correspondenciaUniversidade Metropolitana de Santos
- Raíssa Piagentini de Andrade🇧🇷Universidade Nove de Julho
- Sandra Kalil Bussadori🇧🇷Universidade Nove de Julho
- Raquel Agnelli Mesquita‐Ferrari🇧🇷Universidade Nove de Julho
- Kristianne Porta Santos Fernandes🇧🇷Universidade Nove de Julho
Resumen
El texto original del estudio, en el idioma en que se publicó.
Several therapeutic strategies have been proposed to optimize the conventional treatment of fractures. Photobiomodulation (PBM) appears to help reduce pain and control inflammation, and it also accelerates bone repair. This systematic review aimed to evaluate the effectiveness and safety of PBM with low-level laser therapy (LLLT) in the bone fracture healing process. We included randomized controlled trials (RCTs) comparing the effects of PBM with those of any other intervention in adults with lower or upper limb bone fractures. The primary outcomes investigated were pain reduction, radiographic healing, and adverse events. The searches were conducted in October 2018. Two RCTs were included that compared PBM to the placebo. A meta-analysis showed significant difference in favor of PBM for pain reduction (MD 1.19, 95% CI [0.61 to 1.77], 106 participants, two RCTs), but this difference was not clinically significant. One RCT (50 participants) showed a clinical and statistical improvement in physical function (MD - 14.60, 95% CI [- 21.39 to - 7.81]) and no difference in radiographic healing, regarding absence of fracture line (RR 1.00, 95% CI [0.93 to 1.08]) and visible bone callus (RR 0.33, 95% CI [0.01 to 7.81]). The certainty of evidence was classified as low to very low. Based on the evidence of low to very low certainty, PBM seems to be associated with the improvement of pain and function. Therefore, new RCTs are required that meet the recommendations of CONSORT to prove the effectiveness and safety of this intervention and support its recommendation in clinical practice.
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