Transcriptional changes in prostate of men on active surveillance after a 12-mo glucoraphanin-rich broccoli intervention-results from the Effect of Sulforaphane on prostate CAncer PrEvention (ESCAPE) randomized controlled trial
Traka MH, Melchini A, Coode-Bate J, Al Kadhi O, Saha S, Defernez M, Troncoso-Rey P, Kibblewhite H, O'Neill CM, Bernuzzi F, Mythen L, Hughes J, Needs PW, Dainty JR, Savva GM, Mills RD, Ball RY, Cooper CS, Mithen RF
The American journal of clinical nutrition · 78 citas
Etiquetas de revisión
Alimentación controladaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Prostate Cancer Foundation
- Gobierno
- China Scholarship Council
- Universidad u hospital
- Norfolk and Norwich University Hospitals NHS Foundation Trust
- Gobierno
- Directorate for Biological Sciences
- Gobierno
- Biotechnology and Biological Sciences Research Council
- Subvenciones
- Biotechnology and Biological Sciences Research Council (BBS/E/F/000PR10347); Biotechnology and Biological Sciences Research Council (BBS/E/F/000PR10346); Biotechnology and Biological Sciences Research Council (BBS/E/F/00044600); Biotechnology and Biological Sciences Research Council (BBS/E/F/00044466); Prostate Cancer Foundation (BB/J004545/1); Biotechnology and Biological Sciences Research Council (BBS/E/F/000PR10346); Biotechnology and Biological Sciences Research Council (BBS/E/F/000PR10347); Biotechnology and Biological Sciences Research Council (BBS/E/F/00044466); Biotechnology and Biological Sciences Research Council (BBS/E/F/00042686); Biotechnology and Biological Sciences Research Council (1916087); Biotechnology and Biological Sciences Research Council (BB/J004545/1); Biotechnology and Biological Sciences Research Council (BBS/E/F/00042686)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-01-18 · Am J Clin Nutr · vol. 109 · número 4 · págs. 1133–1144
- Editorial
- Elsevier BV
- Citado
- 106 citas · más que el 94% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Prostate Cancer Treatment and Research · Nutritional Studies and Diet
- Palabras clave
- prostate cancer, active surveillance, glucoraphanin, broccoli, sulforaphane, cruciferous vegetables, gene expression, prostate tissue, tumor progression, inflammation, epithelial-mesenchymal transition, dietary intervention, prostate cancer prevention
- MeSH
- prostate, humans, brassica, prostatic neoplasms, oximes, imidoesters, isothiocyanates, sulfoxides, glucosinolates, gene expression, transcription, genetic, adolescent, adult, aged, aged, 80 and over, middle aged, male, young adult
19 autores
- Μαρία Τράκα🇬🇧Quadram Institute
- Antonietta Melchini🇬🇧Quadram Institute
- Jack Coode‐Bate🇬🇧Norfolk and Norwich University Hospital; Norfolk and Norwich University Hospitals NHS Foundation Trust; Quadram Institute
- Omar Al Kadhi🇬🇧Norfolk and Norwich University Hospital; Norfolk and Norwich University Hospitals NHS Foundation Trust; Quadram Institute
- Shikha Saha🇬🇧Quadram Institute
- Marianne Defernez🇬🇧Quadram Institute
- Perla Troncoso‐Rey🇬🇧Quadram Institute
- Helen Kibblewhite🇬🇧Quadram Institute
- Carmel M. O’Neill🇬🇧Quadram Institute
- Federico Bernuzzi🇬🇧Quadram Institute
- Laura Mythen🇬🇧Quadram Institute
- Jackie C. Hughes🇬🇧Quadram Institute
- Paul W. Needs🇬🇧Quadram Institute
- Jack R. Dainty🇬🇧University of East Anglia
- George M. Savva🇬🇧Quadram Institute
- Robert Mills🇬🇧Norfolk and Norwich University Hospital; Norfolk and Norwich University Hospitals NHS Foundation Trust
- Richard Y. Ball🇬🇧Norfolk and Norwich University Hospital; Norfolk and Norwich University Hospitals NHS Foundation Trust
- Colin S. Cooper🇬🇧University of East Anglia
- Richard F. Mithen🇳🇿🇬🇧 · autor de correspondenciaUniversity of Auckland; Quadram Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Epidemiological evidence suggests that consumption of cruciferous vegetables is associated with reduced risk of prostate cancer progression, largely attributed to the biological activity of glucosinolate degradation products, such as sulforaphane derived from glucoraphanin. Because there are few therapeutic interventions for men on active surveillance for prostate cancer to reduce the risk of cancer progression, dietary approaches are an appealing option for patients.
Objective
We evaluated whether consumption of a glucoraphanin-rich broccoli soup for 1 y leads to changes in gene expression in prostate tissue of men with localized prostate cancer.
Methods
Forty-nine men on active surveillance completed a 3-arm parallel randomized double-blinded intervention study for 12 mo and underwent transperineal template biopsy procedures and dietary assessment at the start and end of the study. Patients received a weekly 300 mL portion of soup made from a standard broccoli (control) or from 1 of 2 experimental broccoli genotypes with enhanced concentrations of glucoraphanin, delivering 3 and 7 times that of the control, respectively. Gene expression in tissues from each patient obtained before and after the dietary intervention was quantified by RNA sequencing followed by gene set enrichment analyses.
Results
In the control arm, there were several hundred changes in gene expression in nonneoplastic tissue during the 12 mo. These were associated with an increase in expression of potentially oncogenic pathways including inflammation processes and epithelial-mesenchymal transition. Changes in gene expression and associated oncogenic pathways were attenuated in men on the glucoraphanin-rich broccoli soup in a dose-dependent manner. Although the study was not powered to assess clinical progression, an inverse association between consumption of cruciferous vegetables and cancer progression was observed.
Conclusion
Consuming glucoraphanin-rich broccoli soup affected gene expression in the prostate of men on active surveillance, consistent with a reduction in the risk of cancer progression. This trial was registered at clinicaltrials.gov as NCT01950143.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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