Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial
Hutchison AT, Regmi P, Manoogian ENC, Fleischer JG, Wittert GA, Panda S, Heilbronn LK
Obesity (Silver Spring, Md.) · 334 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Royal Adelaide Hospital
- Subvenciones
- Royal Adelaide Hospital (561110093)
Según 1 financiador declarado.
Publicación
- Publicado
- 2019-04-19 · Obesity (Silver Spring) · vol. 27 · número 5 · págs. 724–732
- Editorial
- Wiley
- Citado
- 473 citas · más que el 100% de estudios similares · 32.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Circadian rhythm and melatonin · Sleep and related disorders
- Palabras clave
- Postprandial, Medicine, Internal medicine, Glycemic, Type 2 diabetes, Crossover study, Endocrinology, Meal, Area under the curve, Insulin, Diabetes mellitus, Placebo
- MeSH
- humans, diabetes mellitus, type 2, fasting, risk factors, cross-over studies, middle aged, male
7 autores
- Amy T. Hutchison🇦🇺South Australian Health and Medical Research Institute; National Health and Medical Research Council; The University of Adelaide
- Prashant Regmi🇦🇺South Australian Health and Medical Research Institute; National Health and Medical Research Council; The University of Adelaide
- Emily N. C. Manoogian🇺🇸Salk Institute for Biological Studies
- Jason G. Fleischer🇺🇸Salk Institute for Biological Studies
- Gary Wittert🇦🇺South Australian Health and Medical Research Institute; National Health and Medical Research Council; The University of Adelaide
- Satchidananda Panda🇺🇸Salk Institute for Biological Studies
- Leonie Kaye Heilbronn🇦🇺 · autor de correspondenciaSouth Australian Health and Medical Research Institute; National Health and Medical Research Council; The University of Adelaide
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
This study aimed to assess the effects of 9-hour time-restricted feeding (TRF), early (TRFe) or delayed (TRFd), on glucose tolerance in men at risk for type 2 diabetes.
Methods
Fifteen men (age 55 ± 3 years, BMI 33.9 ± 0.8 kg/m2 ) wore a continuous glucose monitor for 7 days of baseline assessment and during two 7-day TRF conditions. Participants were randomized to TRFe (8 am to 5 pm) or TRFd (12 pm to 9 pm), separated by a 2-week washout phase. Glucose, insulin, triglycerides, nonesterified fatty acids, and gastrointestinal hormone incremental areas under the curve were calculated following a standard meal on days 0 and 7 at 8 am (TRFe) or 12 pm (TRFd).
Results
TRF improved glucose tolerance as assessed by a reduction in glucose incremental area under the curve (P = 0.001) and fasting triglycerides (P = 0.003) on day 7 versus day 0. However, there were no mealtime by TRF interactions in any of the variables examined. There was also no effect of TRF on fasting and postprandial insulin, nonesterified fatty acids, or gastrointestinal hormones. Mean fasting glucose by continuous glucose monitor was lower in TRFe (P = 0.02) but not TRFd (P = 0.17) versus baseline, but there was no difference between TRF conditions.
Conclusions
While only TRFe lowered mean fasting glucose, TRF improved glycemic responses to a test meal in men at risk for type 2 diabetes regardless of the clock time that TRF was initiated.
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