Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation
Yang J, Fernández-Galilea M, Martínez-Fernández L, González-Muniesa P, Pérez-Chávez A, Martínez JA, Martínez JA, Moreno-Aliaga MJ
Nutrients · 219 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- “Juan de la Cierva” Grant. Ministry of Sciences, Innovation and Universities
- Gobierno
- CIBER Physiopathology of Obesity and Nutrition (CIBERobn), Carlos III Health Research Institute
- Gobierno
- "Juan de la Cierva" Grant. Ministry of Sciences, Innovation and Universities
- Gobierno
- Ministry of Economy, Industry and Competitiveness (MINECO-FEDER). Government of Spain.
- Gobierno
- Department of Health of the Navarra Government
Según 5 financiadores declarados.
Publicación
- Publicado
- 2019-04-18 · Nutrients · vol. 11 · número 4 · pág. 872
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 299 citas · más que el 100% de estudios similares · 19.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 231 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Liver Disease Diagnosis and Treatment · Diet, Metabolism, and Disease · Liver Disease and Transplantation
- Palabras clave
- Fatty liver, Lipotoxicity, Eicosapentaenoic acid, Oxidative stress, Polyunsaturated fatty acid, Steatohepatitis, Medicine, Internal medicine, Cirrhosis, Docosahexaenoic acid, Fatty acid, Endocrinology, Disease, Biology, Biochemistry, Insulin resistance, Obesity
- MeSH
- humans, fatty acids, omega-3, oxidative stress, aging, non-alcoholic fatty liver disease
7 autores
- Jinchunzi Yang🇪🇸Universidad de Navarra
- Marta Fernández‐Galilea🇪🇸Navarre Institute of Health Research; Universidad de Navarra
- Leyre Martínez‐Fernández🇪🇸Universidad de Navarra
- Pedro González‐Muniesa🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Navarre Institute of Health Research; Universidad de Navarra
- Adriana Pérez-Chávez🇪🇸Universidad de Navarra
- J. Alfredo Martínéz🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Navarre Institute of Health Research; Universidad de Navarra
- María Jesús Moreno-Aliaga🇪🇸 · autor de correspondenciaInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Navarre Institute of Health Research; Universidad de Navarra
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aging is a complex phenomenon characterized by the progressive loss of tissue and organ function. The oxidative-stress theory of aging postulates that age-associated functional losses are due to the accumulation of ROS-induced damage. Liver function impairment and non-alcoholic fatty liver disease (NAFLD) are common among the elderly. NAFLD can progress to non-alcoholic steatohepatitis (NASH) and evolve to hepatic cirrhosis or hepatic carcinoma. Oxidative stress, lipotoxicity, and inflammation play a key role in the progression of NAFLD. A growing body of evidence supports the therapeutic potential of omega-3 polyunsaturated fatty acids (n-3 PUFA), mainly docosahaexenoic (DHA) and eicosapentaenoic acid (EPA), on metabolic diseases based on their antioxidant and anti-inflammatory properties. Here, we performed a systematic review of clinical trials analyzing the efficacy of n-3 PUFA on both systemic oxidative stress and on NAFLD/NASH features in adults. As a matter of fact, it remains controversial whether n-3 PUFA are effective to counteract oxidative stress. On the other hand, data suggest that n-3 PUFA supplementation may be effective in the early stages of NAFLD, but not in patients with more severe NAFLD or NASH. Future perspectives and relevant aspects that should be considered when planning new randomized controlled trials are also discussed.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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