Financiado en parte por Alpro Foundation
Consumption of Meat, Fish, Dairy Products, and Eggs and Risk of Ischemic Heart Disease
Key TJ, Appleby PN, Bradbury KE, Sweeting M, Wood A, Johansson I, Kühn T, Steur M, Weiderpass E, Wennberg M, Lund Würtz AM, Agudo A, Andersson J, Arriola L, Boeing H, Boer JMA, Bonnet F, Boutron-Ruault MC, Cross AJ, Ericson U, Fagherazzi G, Ferrari P, Gunter M, Huerta JM, Katzke V, Khaw KT, Krogh V, La Vecchia C, Matullo G, Moreno-Iribas C, Naska A, Nilsson LM, Olsen A, Overvad K, Palli D, Panico S, Molina-Portillo E, Quirós JR, Skeie G, Sluijs I, Sonestedt E, Stepien M, Tjønneland A, Trichopoulou A, Tumino R, Tzoulaki I, van der Schouw YT, Verschuren WMM, di Angelantonio E, Langenberg C, Forouhi N, Wareham N, Butterworth A, Riboli E, Danesh J
Circulation · 114 citas
Etiquetas de revisión
Vínculos de autores con la industriaCuestionario de frecuencia de consumoFinanciado por la industriaMezcla carne procesada con no procesadaSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
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Quién lo pagó
- Financiación
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- National Institute for Health and Care Research
- Organización sin fines de lucro
- British Heart Foundation
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- European Commission
- Gobierno
- Institut National de la Santé et de la Recherche Médicale
- Gobierno
- Bundesministerium für Bildung und Forschung
- Organización sin fines de lucro
- Cancerfonden
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- Ministero dell’Istruzione, dell’Università e della Ricerca
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- Associazione Italiana per la Ricerca sul Cancro
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- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- Vetenskapsrådet (14136); Hellenic Health Foundation (C8221/A19170); Deutsche Krebshilfe (RD06/0020); Medical Research Council (M012190/1); Hellenic Health Foundation (PI13/01162); Cancer Research UK (RD06/0020); Mutuelle Générale de l'Education Nationale (MR/M012190/1); European Commission (PI13/01162); Institut National de la Santé et de la Recherche Médicale (PI13/01162); Institut Gustave-Roussy (C570/A16491); Associazione Italiana per la Ricerca sul Cancro (PI13/01162); Cancerfonden (C8221/A19170); National Institute for Health and Care Research (NF-SI-0617-10113); Deutsche Krebshilfe (14136); Cancer Research UK (C570/ A16491); Institut Gustave-Roussy (PI13/00061); Instituto de Salud Carlos III (RD06/0020); World Cancer Research Fund (14136); Ligue Contre le Cancer (MR/M012190/1); Ligue Contre le Cancer (PI13/00061); Medical Research Council (C570/A16491); Cancer Research UK (25004); Institut National de la Santé et de la Recherche Médicale (C570/A16491); Ligue Contre le Cancer (C570/A16491); World Cancer Research Fund (PI13/01162); Mutuelle Générale de l'Education Nationale (14136); World Cancer Research Fund (MR/M012190/1); British Heart Foundation (RG/18/13/33946); Bundesministerium für Bildung und Forschung (14136); Associazione Italiana per la Ricerca sul Cancro (PI13/00061); Institut Gustave-Roussy (MR/M012190/1); Ligue Contre le Cancer (C8221/A19170); Deutsche Krebshilfe (MR/M012190/1); Medical Research Council (MC_UU_12015/5); Deutsches Krebsforschungszentrum (C8221/A19170); World Cancer Research Fund (C8221/A19170); Ligue Contre le Cancer (14136); Mutuelle Générale de l'Education Nationale (PI13/00061); National Institute for Health and Care Research ([IS-BRC-1215-20014); Bundesministerium für Bildung und Forschung (C8221/A19170); Institut Gustave-Roussy (C8221/A19170); Medical Research Council (14136); European Commission (RD06/0020); Cancerfonden (14136); Medical Research Council (MR/M012190); Hellenic Health Foundation (PI13/00061); World Cancer Research Fund (C570/A16491); Bundesministerium für Bildung und Forschung (RD06/0020); Institut Gustave-Roussy (14136); Hellenic Health Foundation (C570/A16491); Institut Gustave-Roussy (RD06/0020); Bundesministerium für Bildung und Forschung (MR/M012190/1); British Heart Foundation (G0800270); Hellenic Health Foundation (14136); Ligue Contre le Cancer (PI13/01162); Ligue Contre le Cancer (RD06/0020); Medical Research Council (C8221/A19170); European Commission (C570/A16491); European Commission (C8221/A19170); Medical Research Council (MR/L003120/1); Medical Research Council (RD06/0020); Institut National de la Santé et de la Recherche Médicale (MR/M012190/1); European Commission (14136); Institut National de la Santé et de la Recherche Médicale (C8221/A19170); Medical Research Council (MR/M012190/1); British Heart Foundation (SP/09/002); Deutsche Krebshilfe (C570/A16491); British Heart Foundation (RG/08/014); Ministero dell’Istruzione, dell’Università e della Ricerca (D15D18000410001); Associazione Italiana per la Ricerca sul Cancro (MR/M012190/1); Cancer Research UK (PI13/01162); Wellcome Trust (205212); Associazione Italiana per la Ricerca sul Cancro (14136); Institut National de la Santé et de la Recherche Médicale (RD06/0020); Deutsche Krebshilfe (PI13/00061); Medical Research Council (PI13/01162); European Commission (MR/M012190/1); Vetenskapsrådet (RD06/0020); Institut National de la Santé et de la Recherche Médicale (PI13/00061); Institut National de la Santé et de la Recherche Médicale (14136); Deutsches Krebsforschungszentrum (PI13/01162); Medical Research Council (G0800270); Deutsche Krebshilfe (PI13/01162); World Cancer Research Fund (PI13/00061); Deutsche Krebshilfe (C8221/A19170); Bundesministerium für Bildung und Forschung (PI13/01162); Mutuelle Générale de l'Education Nationale (RD06/0020); Cancer Research UK (14136); Medical Research Council (MR/M012190/1); National Institute for Health and Care Research (NF-SI-0512-10114); Bundesministerium für Bildung und Forschung (PI13/00061); Institut Gustave-Roussy (PI13/01162); European Commission (PI13/00061); Dipartimenti di Eccellenza (D15D18000410001); Deutsches Krebsforschungszentrum (RD06/0020); Cancer Research UK (MR/M012190/1); European Commission (279233); Medical Research Council (PI13/00061); Medical Research Council (MR/N003284/1); Mutuelle Générale de l'Education Nationale (PI13/01162); Cancer Research UK (C8221/A19170); Medical Research Council (MC_UU_12015/1); Cancer Research UK (PI13/00061); Associazione Italiana per la Ricerca sul Cancro (RD06/0020); Mutuelle Générale de l'Education Nationale (C570/A16491); Associazione Italiana per la Ricerca sul Cancro (C570/A16491); Cancer Research UK (570/A16491); Deutsches Krebsforschungszentrum (C570/A16491); Deutsches Krebsforschungszentrum (14136); British Heart Foundation (RG/13/13/30194); Cancerfonden (C570/A16491); Vetenskapsrådet (PI13/00061); Wellcome Trust (205212/Z/16/Z); Medical Research Council (MR/L003120); Mutuelle Générale de l'Education Nationale (C8221/A19170); World Cancer Research Fund (RD06/0020); Associazione Italiana per la Ricerca sul Cancro (C8221/A19170); Deutsches Krebsforschungszentrum (MR/M012190/1); Vetenskapsrådet (PI13/01162); Instituto de Salud Carlos III (01162); Bundesministerium für Bildung und Forschung (C570/A16491); Vetenskapsrådet (C8221/A19170); Hellenic Health Foundation (MR/M012190/1); National Institute for Health and Care Research (NF-SI-0617-10149); Hellenic Health Foundation (RD06/0020); Deutsches Krebsforschungszentrum (PI13/00061); Vetenskapsrådet (C570/A16491); European Commission (37197); Vetenskapsrådet (MR/M012190/1); Medical Research Council (MR/L003120/1)
Según 25 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-04-22 · Circulation · vol. 139 · número 25 · págs. 2835–2845
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 153 citas · más que el 100% de estudios similares · 17.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Fatty Acid Research and Health · Meat and Animal Product Quality
- Palabras clave
- Medicine, Fish <Actinopterygii>, Disease, Consumption (sociology), Food science, Fishery, Internal medicine, Biology
- MeSH
- humans, myocardial ischemia, diet surveys, risk assessment, risk factors, prospective studies, cross-sectional studies, risk reduction behavior, nutritive value, blood pressure, time factors, dairy products, eggs, meat, seafood, adult, aged, middle aged, europe, female, male, cholesterol, hdl, recommended dietary allowances, protective factors, biomarkers, diet, healthy
55 autores
- Timothy J. Key🇬🇧Nuffield Health
- Paul N. Appleby🇬🇧University of Oxford; Nuffield Health
- Kathryn Erica Bradbury🇳🇿🇬🇧University of Auckland; Nuffield Health
- Michael J. Sweeting🇬🇧University of Cambridge; British Heart Foundation
- ANGELA M. WOOD🇬🇧University of Cambridge; British Heart Foundation
- Ingegerd Johansson🇸🇪Umeå University
- Tilman E. Kuhn🇩🇪German Cancer Research Center; Heidelberg University
- Marinka Steur🇬🇧University of Cambridge; Medical Research Council
- Elisabete Weiderpass🇸🇪🇳🇴🇫🇮Karolinska Institutet; Cancer Registry of Norway; Folkhälsans Forskningscentrum; UiT The Arctic University of Norway
- Maria Wennberg🇸🇪Umeå University
- Anne Mette Lund Würtz🇩🇰Aarhus University
- Antonio Agudo🇪🇸Institut d'Investigació Biomédica de Bellvitge
- Jonas S. O. Andersson🇸🇪Skellefteå Hospital; Umeå University
- Larraitz Arriola🇪🇸🇺🇸Basque Government; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Medical Research Network
- Heiner Boeing🇩🇪German Institute of Human Nutrition
- Jolanda M.A. Boer🇳🇱National Institute for Public Health and the Environment
- Fabrice Bonnet🇫🇷Université Paris-Sud; Inserm; Université de Versailles Saint-Quentin-en-Yvelines; Université Paris-Saclay; Institut Gustave Roussy; Université Rennes 2; Centre de recherche en Epidémiologie et Santé des Populations; Centre Hospitalier Universitaire de Rennes; Université de Rennes
- Marie‐Christine Boutron‐Ruault🇫🇷Université Paris-Sud; Inserm; Université de Versailles Saint-Quentin-en-Yvelines; Université Paris-Saclay; Institut Gustave Roussy; Centre de recherche en Epidémiologie et Santé des Populations
- Amanda Jane Cross🇬🇧Imperial College London
- Ulrika Ericson🇸🇪Lund University
- Guy Fagherazzi🇫🇷Université Paris-Sud; Inserm; Université de Versailles Saint-Quentin-en-Yvelines; Université Paris-Saclay; Institut Gustave Roussy; Centre de recherche en Epidémiologie et Santé des Populations
- Pietro Ferrari🇫🇷Centre international de recherche sur le cancer
- Marc James Gunter🇫🇷Centre international de recherche sur le cancer
- José María Huerta🇪🇸Instituto Murciano de Investigación Biosanitaria
- Verena Andrea Katzke🇩🇪German Cancer Research Center; Heidelberg University
- Kay‐Tee Khaw🇬🇧University of Cambridge
- Vittorio Krogh🇮🇹Fondazione IRCCS Istituto Nazionale dei Tumori
- Carlo La Vecchia🇮🇹🇬🇷University of Milan; Hellenic Health Foundation
- Giuseppe Matullo🇮🇹🇧🇾Italian institute for Genomic Medicine; Department of Medical Sciences
- Conchi Moreno‐Iribas🇪🇸Instituto de Salud Pública de Navarra; Navarre Institute of Health Research
- Androniki Naska🇬🇷National and Kapodistrian University of Athens; National Public Health Organization
- Lena Maria Nilsson🇸🇪Arctic Research Centre
- Anja Olsen🇩🇰Danish Cancer Society
- Kim Overvad🇩🇰Aarhus University
- Domenico Palli🇺🇸Prevention Institute
- Salvatore Panico🇮🇹Federico II University Hospital
- Elena Molina‐Portillo🇪🇸Andalusian School of Public Health
- José Ramón Quirós🇪🇸Universidad de Oviedo; Gobierno del Principado de Asturias
- Guri Skeie🇳🇴UiT The Arctic University of Norway
- Ivonne Sluijs🇳🇱🇺🇸University Medical Center Utrecht; Oklahoma State University Center for Health Sciences
- Emily Sonestedt🇸🇪Lund University
- Magdalena Stępień🇫🇷Centre international de recherche sur le cancer
- Anne Marie Tjønneland🇩🇰Danish Cancer Society
- Antonia Trichopoulou🇬🇷National and Kapodistrian University of Athens; Hellenic Health Foundation
- Rosario Tumino🇮🇹Azienda Usl 8 Arezzo; Agenzia Regionale Sanitaria della Puglia
- Ioanna Tzoulaki🇬🇷🇬🇧University of Ioannina; Public Health England; Imperial College London
- Yvonne T. van der Schouw🇳🇱🇺🇸University Medical Center Utrecht; Oklahoma State University Center for Health Sciences
- W. M. Monique Verschuren🇳🇱🇺🇸University Medical Center Utrecht; Oklahoma State University Center for Health Sciences
- Emanuele Di Angelantonio🇬🇧University of Cambridge; British Heart Foundation
- Claudia Langenberg🇬🇧University of Cambridge; Medical Research Council
- Nita G. Forouhi🇬🇧University of Cambridge; Medical Research Council
- Nick Wareham🇬🇧University of Cambridge; Medical Research Council
- Adam S. Butterworth🇬🇧University of Cambridge; British Heart Foundation
- Elio Ríboli🇬🇧Imperial College London
- John Danesh🇬🇧University of Cambridge; British Heart Foundation
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
There is uncertainty about the relevance of animal foods to the pathogenesis of ischemic heart disease (IHD). We examined meat, fish, dairy products, and eggs and risk for IHD in the pan-European EPIC cohort (European Prospective Investigation Into Cancer and Nutrition).
Methods
In this prospective study of 409 885 men and women in 9 European countries, diet was assessed with validated questionnaires and calibrated with 24-hour recalls. Lipids and blood pressure were measured in a subsample. During a mean of 12.6 years of follow-up, 7198 participants had a myocardial infarction or died of IHD. The relationships of animal foods with risk were examined with Cox regression with adjustment for other animal foods and relevant covariates.
Results
The hazard ratio (HR) for IHD was 1.19 (95% CI, 1.06-1.33) for a 100-g/d increment in intake of red and processed meat, and this remained significant after exclusion of the first 4 years of follow-up (HR, 1.25 [95% CI, 1.09-1.42]). Risk was inversely associated with intakes of yogurt (HR, 0.93 [95% CI, 0.89-0.98] per 100-g/d increment), cheese (HR, 0.92 [95% CI, 0.86-0.98] per 30-g/d increment), and eggs (HR, 0.93 [95% CI, 0.88-0.99] per 20-g/d increment); the associations with yogurt and eggs were attenuated and nonsignificant after exclusion of the first 4 years of follow-up. Risk was not significantly associated with intakes of poultry, fish, or milk. In analyses modeling dietary substitutions, replacement of 100 kcal/d from red and processed meat with 100 kcal/d from fatty fish, yogurt, cheese, or eggs was associated with ≈20% lower risk of IHD. Consumption of red and processed meat was positively associated with serum non-high-density lipoprotein cholesterol concentration and systolic blood pressure, and consumption of cheese was inversely associated with serum non-high-density lipoprotein cholesterol.
Conclusions
Risk for IHD was positively associated with consumption of red and processed meat and inversely associated with consumption of yogurt, cheese, and eggs, although the associations with yogurt and eggs may be influenced by reverse causation bias. It is not clear whether the associations with red and processed meat and cheese reflect causality, but they were consistent with the associations of these foods with plasma non-high-density lipoprotein cholesterol and for red and processed meat with systolic blood pressure, which could mediate such effects.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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