Omega-3 and omega-6 polyunsaturated fatty acids and metabolic syndrome: A systematic review and meta-analysis
Jang H, Park K
Clinical nutrition (Edinburgh, Scotland) · 75 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Research Foundation of Korea
- Subvenciones
- National Research Foundation of Korea (NRF-2017R1A1A3A04069759)
Según 1 financiador declarado.
Publicación
- Publicado
- 2019-04-05 · Clin Nutr · vol. 39 · número 3 · págs. 765–773
- Editorial
- Elsevier BV
- Citado
- 123 citas · más que el 96% de estudios similares · 4.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 59 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Diet, Metabolism, and Disease
- Palabras clave
- omega-3 polyunsaturated fatty acids, omega-6 fatty acids, metabolic syndrome, dietary fatty acid intake, circulating fatty acids, Asian populations, ethnic differences in risk
- MeSH
- humans, fatty acids, omega-3, fatty acids, omega-6, diet, metabolic syndrome
2 autores
- Haeun Jang🇰🇷Yeungnam University
- Kyong Park🇰🇷 · autor de correspondenciaYeungnam University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Previous studies suggest that polyunsaturated fatty acids (PUFAs) may reduce the risk of metabolic diseases, but some have shown ambiguous results. The aim of this study was to systematically evaluate and summarize available evidence on the association between omega-3 and omega-6 PUFA levels and risk of metabolic syndrome (MetS).
Methods
A systematic literature search of articles published until December 2017 was conducted in PubMed, Web of Science, and Cochrane Library databases. Meta-analyses of the highest vs. lowest categories of omega-3 and omega-6 PUFAs were conducted using the random effects models.
Results
Thirteen studies (2 case-control, 9 cross-sectional, 1 nested case-control, and 1 prospective cohort) with 36,542 individuals were included. Higher omega-3 PUFA levels in diets or blood were associated with a 26% reduction in the risk of MetS (odds ratio (OR)/relative risk (RR) 0.74, 95% confidence interval (CI) 0.62-0.89). This inverse association was evident among studies with Asian populations (OR/RR 0.69, 95% CI 0.54-0.87), but not among those with American/European populations (OR/RR 0.84, 95% CI 0.55-1.28). Null results were found regarding the association between circulating/dietary omega-6 PUFAs and MetS.
Conclusion
The present meta-analysis indicates that higher intakes of omega-3 PUFAs, but not omega-6 PUFAs, was associated with lower MetS risk; adding to the current body of evidence on the metabolic health effects of circulating/dietary omega-3 PUFAs.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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