Cardiovascular Benefits of Fish-Oil Supplementation Against Fine Particulate Air Pollution in China
Lin Z, Chen R, Jiang Y, Xia Y, Niu Y, Wang C, Liu C, Chen C, Ge Y, Wang W, Yin G, Cai J, Clement V, Xu X, Chen B, Chen H, Kan H
Journal of the American College of Cardiology · 95 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- China Medical Board
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China ((91843302); National Natural Science Foundation of China (91743111); China Medical Board (16–250); National Natural Science Foundation of China (91643205)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2019-04-01 · J Am Coll Cardiol · vol. 73 · número 16 · págs. 2076–2085
- Editorial
- Elsevier BV
- Citado
- 125 citas · más que el 99% de estudios similares · 11.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Air Quality and Health Impacts · Antioxidant Activity and Oxidative Stress
- Palabras clave
- fish oil supplementation, omega-3 fatty acids, PM2.5, air pollution health effects, cardioprotection, subclinical inflammation, coagulation, endothelial function, oxidative stress, antioxidant activity, neuroendocrine stress response, young adults, dietary supplements
- MeSH
- humans, cardiovascular diseases, fish oils, double-blind method, air pollution, environmental exposure, primary prevention, reference values, dietary supplements, china, female, male, particulate matter, young adult, healthy volunteers
17 autores
- Zhijing Lin🇨🇳Fudan University
- Renjie Chen🇨🇳Fudan University
- Yixuan Jiang🇨🇳Fudan University
- Yongjie Xia🇨🇳Fudan University
- Yue Niu🇨🇳Fudan University
- Cuiping Wang🇨🇳Fudan University
- Cong Liu🇨🇳Fudan University
- Chen Chen🇨🇳Fudan University
- Yihui Ge🇨🇳Fudan University
- Weidong Wang🇨🇳Fudan University
- Guanjin Yin🇨🇳Fudan University
- Jing Cai🇨🇳Fudan University
- Viviane Clément🇺🇸Texas A&M University
- Xiaohui Xu🇺🇸Texas A&M University
- Bo Chen🇨🇳Fudan University
- Honglei Chen🇺🇸Michigan State University
- Haidong Kan🇨🇳 · autor de correspondenciaFudan University; Children's Hospital of Fudan University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Few studies have evaluated the health benefits of omega-3 fatty acid supplementation against fine particulate matter (aerodynamic diameter 2.5]) exposure in highly polluted areas.
Objectives
The authors sought to evaluate whether dietary fish-oil supplementation protects cardiovascular health against PM2.5 exposure in China.
Methods
This is a randomized, double-blinded, and placebo-controlled trial among 65 healthy college students in Shanghai, China. Participants were randomly assigned to either the placebo group or the intervention group with dietary fish-oil supplementation of 2.5 g/day from September 2017 to January 2018, and received 4 rounds of health examinations in the last 2 months of treatments. Fixed-site PM2.5 concentrations on campus were measured in real time. The authors measured blood pressure and 18 biomarkers of systematic inflammation, coagulation, endothelial function, oxidative stress, antioxidant activity, cardiometabolism, and neuroendocrine stress response. Acute effects of PM2.5 on these outcomes were evaluated within each group using linear mixed-effect models.
Results
The average PM2.5 level was 38 μg/m3 during the study period. Compared with the placebo group, the fish-oil group showed relatively stable levels of most biomarkers in response to changes in PM2.5 exposure. Between-group differences associated with PM2.5 exposure varied by biomarkers and by lags of exposure. The authors observed beneficial effects of fish-oil supplementation on 5 biomarkers of blood inflammation, coagulation, endothelial function, oxidative stress, and neuroendocrine stress response in the fish-oil group at a false discovery rate of <0.05.
Conclusions
This trial shows that omega-3 fatty acid supplementation is associated with short-term subclinical cardiovascular benefits against PM2.5 exposure among healthy young adults in China. (Effect of Dietary Supplemental Fish Oil in Alleviating Health Hazards Associated With Air Pollution; NCT03255187).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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