A Prospective Study of Nut Consumption and Risk of Primary Hepatocellular Carcinoma in the U.S. Women and Men
Sui J, Yang W, Ma Y, Li TY, Simon TG, Meyerhardt JA, Liang G, Giovannucci EL, Chan AT, Zhang X
Cancer prevention research (Philadelphia, Pa.) · 19 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Cancer Society
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NCI NIH HHS
- Gobierno
- NIH
- Organización sin fines de lucro
- American Cancer Society Research Scholar Grant
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Cancer Institute (U01 CA167552); National Cancer Institute (R03 CA176717); National Cancer Institute (P01 CA087969); National Cancer Institute (UM1 CA186107); National Cancer Institute (UM1-CA-167552); National Cancer Institute (K07 CA188126); American Cancer Society (RSG130476); National Institute of Diabetes and Digestive and Kidney Diseases (K24 [DK]098311); National Institutes of Health (K24 DK098311); National Institutes of Health (K07CA188126)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2019-04-30 · Cancer Prev Res (Phila) · vol. 12 · número 6 · págs. 367–374
- Editorial
- American Association for Cancer Research
- Citado
- 23 citas · más que el 81% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 57 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Nuts composition and effects · Horticultural and Viticultural Research · Peanut Plant Research Studies
- Palabras clave
- Hepatocellular carcinoma, Nut, Medicine, Consumption (sociology), Prospective cohort study, Environmental health, Primary prevention, Oncology, Internal medicine, Demography, Sociology, Disease
- MeSH
- humans, nuts, carcinoma, hepatocellular, liver neoplasms, prognosis, risk factors, case-control studies, follow-up studies, prospective studies, feeding behavior, adult, aged, middle aged, united states, female, male
10 autores
- Jing Sui🇺🇸🇨🇳Brigham and Women's Hospital; Southeast University
- Wanshui Yang🇺🇸🇨🇳Brigham and Women's Hospital; Anhui Medical University
- Yanan Ma🇺🇸🇨🇳Brigham and Women's Hospital; China Medical University
- Tricia Y. Li🇺🇸Brigham and Women's Hospital
- Tracey G. Simon🇺🇸Massachusetts General Hospital
- Jeffrey A. Meyerhardt🇺🇸Dana-Farber Cancer Institute
- Geyu Liang🇨🇳Southeast University
- Edward L. Giovannucci🇺🇸Harvard University
- Andrew Tan Chan🇺🇸Brigham and Women's Hospital; Massachusetts General Hospital
- Xuehong Zhang🇺🇸 · autor de correspondenciaBrigham and Women's Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Although increasing evidence suggests a potential beneficial effect of nut consumption on various diseases, no epidemiologic study has yet examined the association between nut consumption and risk of hepatocellular carcinoma (HCC). We prospectively examined this association in 88,783 women from the Nurses' Health Study and 51,492 men from the Health Professionals Follow-up Study. Nut consumption was assessed every 4 years using validated food frequency questionnaires. Multivariable HRs and 95% confidence intervals (95% CI) were estimated using Cox proportional hazards regression models after adjusting for HCC risk factors. After an average of 27.9 years of follow-up, we identified a total of 162 incident HCC cases. Higher total nut consumption was not significantly associated with HCC risk (the highest vs. lowest tertile intake, HR, 0.84; 95% CI, 0.56-1.26). For the same comparison, higher tree nut consumption was associated with a lower HCC risk (HR, 0.64; 95% CI, 0.43-0.95). We found nonsignificant inverse associations with consumption of walnuts, peanuts, and peanut butter. Overall, nut consumption was not strongly associated with HCC risk. There was a suggestive inverse association with tree nut consumption. Future studies should carefully consider hepatitis B or C virus infections and examine these associations in other racial/ethnic groups.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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