Egg Consumption and Risk of Upper Aero-Digestive Tract Cancers: A Systematic Review and Meta-Analysis of Observational Studies
Aminianfar A, Fallah-Moshkani R, Salari-Moghaddam A, Saneei P, Larijani B, Esmaillzadeh A
Advances in nutrition (Bethesda, Md.) · 8 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Tehran University of Medical Sciences and Health Services
- Universidad u hospital
- Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences
- Universidad u hospital
- Tehran University of Medical Sciences
Según 3 financiadores declarados.
Publicación
- Publicado
- 2019-01-19 · Adv Nutr · vol. 10 · número 4 · págs. 660–672
- Editorial
- Elsevier BV
- Citado
- 11 citas · más que el 45% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 83 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Head and Neck Cancer Studies · Esophageal Cancer Research and Treatment
- Palabras clave
- egg consumption, upper aerodigestive tract cancer, oropharyngeal cancer, laryngeal cancer, esophageal cancer, cancer risk, dietary factors, hospital-based case-control study, population-based case-control study, prospective cohort, dietary exposure assessment, nutrition and cancer prevention
- MeSH
- humans, head and neck neoplasms, risk factors, case-control studies, feeding behavior, eggs, adolescent, adult, aged, aged, 80 and over, middle aged, female, male, young adult, observational studies as topic
6 autores
- Azadeh Aminianfar · autor de correspondencia
- Roohallah Fallah-Moshkani🇮🇷Obesity and Eating Habits Research Center; Endocrinology and Metabolism Molecular-Cellular Sciences Institute; Tehran University of Medical Sciences
- Asma Salari-Moghaddam
- Parvane Saneei🇮🇷Obesity and Eating Habits Research Center; Endocrinology and Metabolism Molecular-Cellular Sciences Institute; Tehran University of Medical Sciences
- Bagher A. Larijani
- Ahmad Esmaillzadeh🇮🇷Isfahan University of Medical Sciences; Endocrinology and Metabolism Clinical Sciences Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Limited data are available that summarize the relation between egg intake and the risk of upper aero-digestive tract (UADT) cancers. This systematic review and meta-analysis was conducted to investigate the association between egg intake and the risk of UADT cancers. Medline/PubMed, ISI web of knowledge, EMBASE, Scopus, and Google Scholar were searched using relevant keywords. Observational studies conducted on humans investigating the association between egg consumption and the risk of UADT cancers were included. Overall, 38 studies with a total of 164,241 subjects (27, 025 cases) were included. Based on 40 effect sizes from 32 case-control studies, we found a 42% increased risk of UADT cancers among those with the highest egg consumption (ranging from ≥1 meal/d to ≥1 time/mo among studies) compared to those with the lowest intake (ranging from 0-20 g/d to never consumed among studies) (overall OR: 1.42; 95% CI: 1.19, 1.68; P < 0.001). However, this association was only evident in hospital-based case-control (HCC) studies (OR = 1.50; 95% CI: 1.34, 1.68; P < 0.001 for 'oropharyngeal and laryngeal cancer' and OR: 1.27; 95% CI: 1.08, 1.50; P = 0.004 for esophageal cancer) and not in population-based case-control (PCC) studies (OR = 1.25; 95% CI: 0.59, 2.67; P = 0.56 for 'oropharyngeal and laryngeal cancer' and OR: 1.29; 95% CI: 0.92, 1.81; P = 0.13 for esophageal cancer). In addition, the association was not significant in prospective cohort studies (overall OR: 0.86; 95% CI: 0.71, 1.04; P = 0.11). Considering individual cancers, a positive association was observed between the highest egg consumption, compared with the lowest, and risk of oropharyngeal (OR: 1.88; 95% CI: 1.61, 2.20; P < 0.001), laryngeal (OR: 1.83; 95% CI: 1.45, 2.32; P < 0.001), oral & pharyngeal & laryngeal (OR: 1.37; 95% CI: 1.12, 1.67; P < 0.001), and esophageal cancers (OR: 1.28; 95% CI: 1.10,1.48; P = 0.001). We also found an inverse association between egg intake and the risk of oral cancer (OR: 0.78; 95% CI: 0.62, 0.99; P = 0.04). In conclusion, high egg consumption (ranging from ≥1 meal/d to ≥1 time/mo among studies) was associated with increased risk of UADT cancers only in HCC studies but not in PCC or prospective cohort studies. PROSPERO registration number: CRD42018102619.
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