Altered brain structure with preserved cortical motor activity after exertional hypohydration: a MRI study
Tan XR, Low ICC, Stephenson MC, Kok T, Nolte HW, Soong TW, Lee JKW
Journal of applied physiology (Bethesda, Md. : 1985) · 11 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministry of Defence, Singapore
- Gobierno
- Ministry Of Defence- Singapore (MINDEF)
- Subvenciones
- Ministry of Defence, Singapore (9015102335)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2019-05-02 · J Appl Physiol (1985) · vol. 127 · número 1 · págs. 157–167
- Editorial
- American Physiological Society
- Citado
- 15 citas · más que el 75% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 61 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Thermoregulation and physiological responses · Diet and metabolism studies · Muscle metabolism and nutrition
- Palabras clave
- Cardiology, Magnetic resonance imaging, Medicine, Perfusion, Internal medicine, VO2 max, Treadmill, Heart rate, Blood pressure
- MeSH
- brain, humans, dehydration, magnetic resonance imaging, exercise test, body temperature, fluid therapy, exercise, motor activity, oxygen consumption, body temperature regulation, sweating, heart rate, drinking, running, adult, male, young adult
7 autores
- Xiang Ren Tan🇸🇬National University of Singapore
- Ivan Cherh Chiet Low🇸🇬National University of Singapore
- Mary C. Stephenson🇸🇬National University of Singapore
- Timothy K. T. Kok🇸🇬National University of Singapore
- Heinrich W. Nolte🇿🇦University of the Witwatersrand
- T. W. Soong🇸🇬National University of Singapore
- JASON KAI WEI LEE🇸🇬 · autor de correspondenciaNational University of Singapore; Global Asia Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Hypohydration exceeding 2% body mass can impair endurance capacity. It is postulated that the brain could be perturbed by hypohydration, leading to impaired motor performance. We investigated the neural effects of hypohydration with magnetic resonance imaging (MRI). Ten men were dehydrated to approximately -3% body mass by running on a treadmill at 65% maximal oxygen consumption (V̇o2max) before drinking to replace either 100% [euhydration (EU)] or 0% [hypohydration (HH)] of fluid losses. MRI was performed before start of trial (baseline) and after rehydration phase (post) to evaluate brain structure, cerebral perfusion, and functional activity. Endurance capacity assessed with a time-to-exhaustion run at 75% V̇o2max was reduced with hypohydration (EU: 45.2 ± 9.3 min, HH: 38.4 ± 10.7 min; P = 0.033). Mean heart rates were comparable between trials (EU: 162 ± 5 beats/min, HH: 162 ± 4 beats/min; P = 0.605), but the rate of rise in rectal temperature was higher in HH trials (EU: 0.06 ± 0.01°C/min, HH: 0.07 ± 0.02°C/min; P P = 0.637). Our findings demonstrate that with exertional hypohydration, brain volumes were altered but the motor-related functional activity was unperturbed. NEW & NOTEWORTHY Dehydration occurs rapidly during prolonged or intensive physical activity, leading to hypohydration if fluid replenishment is insufficient to replace sweat losses. Altered hydration status poses an osmotic challenge for the brain, leading to transient fluctuations in brain tissue and ventricle volumes. Therefore, the amount of fluid ingestion during exercise plays a critical role in preserving the integrity of brain architecture. These structural changes, however, did not translate directly to motor functional deficits in a simple motor task.
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