Serum 25-hydroxyvitamin D is associated with obesity and metabolic parameters in US children
Fu Z, Xu C, Shu Y, Xie Z, Lu C, Mo X
Public health nutrition · 36 citas
Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Key Research and Development Program of China
- Subvenciones
- National Key Research and Development Program of China (2016YFC1101001); National Key Research and Development Program of China (2017YFC1308105)
Según 1 financiador declarado.
Publicación
- Publicado
- 2019-05-23 · Public Health Nutr · vol. 23 · número 7 · págs. 1214–1222
- Editorial
- Cambridge University Press
- Citado
- 51 citas · más que el 93% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 58 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Sexual Differentiation and Disorders
- Palabras clave
- Medicine, Insulin resistance, Obesity, Vitamin D and neurology, Internal medicine, vitamin D deficiency, Odds ratio, Metabolic syndrome, Endocrinology, Population, National Health and Nutrition Examination Survey, Odds, Logistic regression, Environmental health
- MeSH
- humans, insulin resistance, vitamin d deficiency, blood glucose, lipids, vitamin d, body mass index, nutrition surveys, risk factors, cross-sectional studies, adolescent, child, united states, female, male, adiposity, cholesterol, hdl, pediatric obesity, metabolic syndrome
6 autores
- Zhi Fu🇨🇳Huaian First People’s Hospital; Second Affiliated Hospital of Nanjing Medical University; Nanjing Medical University
- Cheng Yu Xu🇨🇳Second Affiliated Hospital of Nanjing Medical University
- Yaqin Shu🇨🇳Second Affiliated Hospital of Nanjing Medical University
- Zongyun Xie🇨🇳Second Affiliated Hospital of Nanjing Medical University
- Changgui Lu🇨🇳Second Affiliated Hospital of Nanjing Medical University
- Xuming Mo🇨🇳 · autor de correspondenciaSecond Affiliated Hospital of Nanjing Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To explore the relationships of serum 25-hydroxyvitamin D (25(OH)D) with obesity and metabolic parameters in US children.
Design
Cross-sectional analysis. We evaluated the associations between serum 25(OH)D and multiple measurements of adiposity, serum lipid concentrations, fasting glucose and insulin resistance in children aged 6-18 years with adjustments for multiple covariates.
Setting
The National Health and Nutrition Examination Survey, 2001-2006.
Participants
A nationally representative sample of 6311 children and adolescents aged 6-18 years.
Results
Among US children and adolescents, the prevalence of vitamin D deficiency has been especially high in older children, girls and the non-Hispanic Black population. Higher odds of obesity were found at a 25(OH)D concentration of 50 nmol/l under both criteria for obesity in children (OR = 3·27, Ptrend ≤ 0.001). Moreover, increased odds of having abnormal HDL-cholesterol (OR = 1·71, Ptrend ≤ 0.001) and impaired insulin resistance (OR = 4·15, Ptrend ≤ 0·001) were found for children deficient in 25(OH)D compared with those with normal 25(OH)D concentrations. When the children and adolescents were stratified by gender, we found stronger associations between serum 25(OH)D concentration and both HDL-cholesterol and insulin resistance in girls. No association of 25(OH)D with any other metabolic parameter was found.
Conclusions
Our results suggest a potential harmful association between low serum 25(OH)D concentration and the risk of obesity among children. However, the underlying mechanisms require further investigation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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