Financiado en parte por Novo Nordisk, Novo Nordisk Fonden
A Joint Modeling Approach for Childhood Meat, Fish and Egg Consumption and the Risk of Advanced Islet Autoimmunity
Syrjälä E, Nevalainen J, Peltonen J, Peltonen J, Takkinen HM, Hakola L, Åkerlund M, Veijola R, Ilonen J, Toppari J, Knip M, Virtanen SM
Scientific reports · 20 citas
Etiquetas de revisión
Financiado por la industriaSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Organización sin fines de lucro
- Juvenile Diabetes Research Foundation International
- Gobierno
- European Commission
- Organización sin fines de lucro
- European Foundation for the Study of Diabetes
- Gobierno
- Academy of Finland
- Organización sin fines de lucro
- Juho Vainion Säätiö
- Empresa
- Novo Nordisk
- Organización sin fines de lucro
- Diabetesliitto
- Empresa
- Novo Nordisk Fonden
- Sin clasificar
- Tays
- Universidad u hospital
- Turun Yliopistollinen Keskussairaala
- Organización sin fines de lucro
- Diabetestutkimussäätiö
- Gobierno
- Fonds Spéciaux de Recherche
- Subvenciones
- Academy of Finland (79 686); Academy of Finland (20122017); Academy of Finland (126813); Academy of Finland (114666); Academy of Finland (308 066); Juvenile Diabetes Research Foundation International (4‐1998‐274); Juvenile Diabetes Research Foundation International (4‐1999‐731); European Commission (250114); Academy of Finland (63 672); European Commission (276475); Juvenile Diabetes Research Foundation International (68292); Juvenile Diabetes Research Foundation International (4-1998-274, 4-1999-731, 4-2001-435); Academy of Finland (201 988); Academy of Finland (68292); Academy of Finland (129 492); European Commission (BMH4‐CT98‐3314); Academy of Finland (80 846); Juho Vainion Säätiö (9H092); Academy of Finland (210 632); Tays (9S074); Juho Vainion Säätiö (9M036); Diabetestutkimussäätiö (BMH4-CT98-3314); Academy of Finland (276475); European Commission (4-1998-274); Juho Vainion Säätiö (9P057); Academy of Finland (250114); Tays (9P057); Juho Vainion Säätiö (9G087); Academy of Finland (139391); Juho Vainion Säätiö (9R055); Juho Vainion Säätiö (9K149); Tays (9R055); Juho Vainion Säätiö (9F089); Academy of Finland (Decision No. 250114); Juho Vainion Säätiö (9S074); European Commission (4-1999-731); Diabetestutkimussäätiö (250114); Academy of Finland (79 685); Juho Vainion Säätiö (9J147); Juho Vainion Säätiö (9N086); European Commission (68292); Juho Vainion Säätiö (9L042); Juvenile Diabetes Research Foundation International (4‐2001‐435); European Commission (4-2001-435); Juho Vainion Säätiö (9E082); Juho Vainion Säätiö (9L117); Academy of Finland (Physiology Research 2012-2017)
Según 12 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-05-23 · Sci Rep · vol. 9 · número 1 · pág. 7760
- Editorial
- Nature Portfolio
- Citado
- 22 citas · más que el 85% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Diabetes and associated disorders · Diet, Metabolism, and Disease · Pancreatic function and diabetes
- Palabras clave
- Hazard ratio, Proportional hazards model, Confounding, Medicine, Prospective cohort study, Type 1 diabetes, Population, Cohort, Diabetes mellitus, Cohort study, Environmental health, Internal medicine, Confidence interval, Endocrinology
- MeSH
- islets of langerhans, animals, fishes, humans, diabetes mellitus, type 1, food hypersensitivity, genetic predisposition to disease, autoantibodies, diet therapy, diet, models, statistical, proportional hazards models, risk factors, cohort studies, prospective studies, autoimmunity, eggs, meat, adolescent, child, child, preschool, infant, infant, newborn, finland, female, male, hla-dq beta-chains
11 autores
- Essi Syrjälä🇫🇮 · autor de correspondenciaTampere University; Tampere University
- Jaakko Nevalainen🇫🇮Tampere University
- Jaakko Peltonen🇫🇮Tampere University
- Hanna‐Mari Takkinen🇫🇮Tampere University; Finnish Institute for Health and Welfare
- Leena Hakola🇫🇮Tampere University
- Iris Erlund🇫🇮Tampere University; Finnish Institute for Health and Welfare
- Riitta Veijola🇫🇮Oulu University Hospital; University of Oulu
- Jorma Ilonen🇫🇮University of Turku; Turku University Hospital
- Jorma Toppari🇫🇮University of Turku; Turku University Hospital
- Mikael Knip🇫🇮University of Helsinki; Helsinki University Hospital; Helsinki Children's Hospital; Tampere University Hospital; Tampere University; Folkhälsans Forskningscentrum
- Suvi Mirjami Virtanen🇫🇮Tampere University; Finnish Institute for Health and Welfare; Tampere University Hospital; Tampere University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Several dietary factors have been suspected to play a role in the development of advanced islet autoimmunity (IA) and/or type 1 diabetes (T1D), but the evidence is fragmentary. A prospective population-based cohort of 6081 Finnish newborn infants with HLA-DQB1-conferred susceptibility to T1D was followed up to 15 years of age. Diabetes-associated autoantibodies and diet were assessed at 3- to 12-month intervals. We aimed to study the association between consumption of selected foods and the development of advanced IA longitudinally with Cox regression models (CRM), basic joint models (JM) and joint latent class mixed models (JLCMM). The associations of these foods to T1D risk were also studied to investigate consistency between alternative endpoints. The JM showed a marginal association between meat consumption and advanced IA: the hazard ratio adjusted for selected confounding factors was 1.06 (95% CI: 1.00, 1.12). The JLCMM identified two classes in the consumption trajectories of fish and a marginal protective association for high consumers compared to low consumers: the adjusted hazard ratio was 0.68 (0.44, 1.05). Similar findings were obtained for T1D risk with adjusted hazard ratios of 1.13 (1.02, 1.24) for meat and 0.45 (0.23, 0.86) for fish consumption. Estimates from the CRMs were closer to unity and CIs were narrower compared to the JMs. Findings indicate that intake of meat might be directly and fish inversely associated with the development of advanced IA and T1D, and that disease hazards in longitudinal nutritional epidemiology are more appropriately modeled by joint models than with naive approaches.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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