Differential Anti-Adipogenic Effects of Eicosapentaenoic and Docosahexaenoic Acids in Obesity
Zhuang P, Lu Y, Shou Q, Mao L, He L, Wang J, Chen J, Zhang Y, Jiao J
Molecular nutrition & food research · 32 citas
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (81300309); National Natural Science Foundation of China (81773419)
Según 1 financiador declarado.
Publicación
- Publicado
- 2019-05-29 · Mol Nutr Food Res · vol. 63 · número 14 · pág. e1801135
- Editorial
- Wiley
- Citado
- 46 citas · más que el 95% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 63 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Adipose Tissue and Metabolism · Eicosanoids and Hypertension Pharmacology
- Palabras clave
- Eicosapentaenoic acid, Docosahexaenoic acid, Internal medicine, Endocrinology, Adipogenesis, Adipose tissue, White adipose tissue, Overweight, Chemistry, Population, Obesity, Medicine, Fatty acid, Food science, Polyunsaturated fatty acid, Biochemistry
- MeSH
- 3t3-l1 cells, animals, mice, inbred c57bl, humans, mice, obesity, docosahexaenoic acids, eicosapentaenoic acid, anti-obesity agents, nutrition surveys, dietary supplements, middle aged, united states, female, male, adipogenesis, body fat distribution, adipose tissue, white, diet, high-fat
9 autores
- Pan Zhuang🇨🇳Ministry of Agriculture and Rural Affairs; Zhejiang University
- Yanhua Lu🇨🇳Hangzhou Normal University
- Qiyang Shou🇨🇳Zhejiang Chinese Medical University
- Lei Mao🇨🇳Zhejiang University
- Lilin He🇨🇳Ministry of Agriculture and Rural Affairs; Zhejiang University
- Jun Wang🇨🇳Ministry of Agriculture and Rural Affairs; Zhejiang University
- Jingnan Chen🇨🇳Ministry of Agriculture and Rural Affairs; Zhejiang University
- Yu Zhang🇨🇳 · autor de correspondenciaMinistry of Agriculture and Rural Affairs; Zhejiang University
- Jingjing Jiao🇨🇳 · autor de correspondenciaZhejiang University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Scope
To assess the associations of plasma eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) with body fat in a population-based sample and explore the mechanism of action based on browning of white adipose tissue (WAT) in high-fat-diet-induced obese (DIO) mice and 3T3-L1 adipocytes.
Methods and results
Plasma EPA and DHA of 1719 adults in the National Health and Nutrition Examination Survey (2003-2004) are determined by gas chromatography mass spectrometry, while total body fat is measured by dual-energy X-ray absorptiometry. DIO mice are fed a high-fat diet supplemented with EPA or DHA (1% wt/wt) for 15 weeks and 3T3-L1 preadipocytes are treated with EPA or DHA during differentiation. Plasma DHA but not EPA is associated with lower body fat mass (ptrend trend = 0.02). DHA supplementation reduces inguinal WAT and exhibits a more pronounced thermogenic effect than EPA in DIO mice. In vitro, the browning process is induced after 2-day and 6-day treatment with DHA and EPA, respectively.
Conclusion
Plasma DHA but not EPA is inversely associated with body fat mass. The more potent anti-adipogenic effect of DHA than EPA may involve a better capability of inducing browning of WAT for DHA.
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