Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans
Jamshed H, Beyl RA, Della Manna DL, Yang ES, Ravussin E, Peterson CM
Nutrients · 514 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Obesity Society
- Universidad u hospital
- University of Alabama at Birmingham
- Universidad u hospital
- University of Alabama
- Universidad u hospital
- Louisiana Clinical and Translational Science Center
- Gobierno
- National Institutes of Health
- Universidad u hospital
- Nutrition Obesity Research Center, University of North Carolina
- Gobierno
- National Institute of General Medical Sciences
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NIGMS NIH HHS
- Gobierno
- NCATS NIH HHS
- Organización sin fines de lucro
- The Obesity Society
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079626); National Institute of General Medical Sciences (P30 DK072476); National Institute of General Medical Sciences (U54‐ GM104940); Nutrition Obesity Research Center, University of North Carolina (#P30DK072476); Nutrition Obesity Research Center, University of North Carolina (DK072476); Louisiana Clinical and Translational Science Center (U54GM104940); National Institute of General Medical Sciences (GM104940); National Center for Advancing Translational Sciences (KL2 TR001419); Louisiana Clinical and Translational Science Center (GM104940); National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK-072476); Nutrition Obesity Research Center, University of North Carolina (U54 GM104940); National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK-056336)
Según 13 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-05-30 · Nutrients · vol. 11 · número 6 · pág. 1234
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 671 citas · más que el 100% de estudios similares · 33.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 69 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Circadian rhythm and melatonin · Diet and metabolism studies
- Palabras clave
- Circadian rhythm, Endocrinology, Morning, Internal medicine, Evening, CLOCK, Circadian clock, Biology, Hormone, Autophagy, Gene expression, Carbohydrate metabolism, TXNIP, Medicine, Gene, Genetics, Oxidative stress, Apoptosis
- MeSH
- humans, blood glucose, fasting, cross-over studies, gene expression regulation, circadian rhythm, aging, eating, time factors, autophagy, meals, biomarkers
6 autores
- Humaira Jamshed🇺🇸University of Alabama at Birmingham
- Robbie A. Beyl🇺🇸Pennington Biomedical Research Center
- Deborah Della Manna🇺🇸University of Alabama at Birmingham
- Eddy Shih-Hsin Yang🇺🇸University of Alabama at Birmingham
- Éric Ravussin🇺🇸Pennington Biomedical Research Center
- Courtney M. Peterson🇺🇸 · autor de correspondenciaUniversity of Alabama at Birmingham
Resumen
El texto original del estudio, en el idioma en que se publicó.
Time-restricted feeding (TRF) is a form of intermittent fasting that involves having a longer daily fasting period. Preliminary studies report that TRF improves cardiometabolic health in rodents and humans. Here, we performed the first study to determine how TRF affects gene expression, circulating hormones, and diurnal patterns in cardiometabolic risk factors in humans. Eleven overweight adults participated in a 4-day randomized crossover study where they ate between 8 am and 2 pm (early TRF (eTRF)) and between 8 am and 8 pm (control schedule). Participants underwent continuous glucose monitoring, and blood was drawn to assess cardiometabolic risk factors, hormones, and gene expression in whole blood cells. Relative to the control schedule, eTRF decreased mean 24-hour glucose levels by 4 ± 1 mg/dl (p = 0.0003) and glycemic excursions by 12 ± 3 mg/dl (p = 0.001). In the morning before breakfast, eTRF increased ketones, cholesterol, and the expression of the stress response and aging gene SIRT1 and the autophagy gene LC3A (all p p = 0.10) and also increased the expression of MTOR (p = 0.007), a major nutrient-sensing protein that regulates cell growth. eTRF also altered the diurnal patterns in cortisol and the expression of several circadian clock genes (p < 0.05). eTRF improves 24-hour glucose levels, alters lipid metabolism and circadian clock gene expression, and may also increase autophagy and have anti-aging effects in humans.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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