Sulforaphane Bioavailability and Chemopreventive Activity in Men Presenting for Biopsy of the Prostate Gland: A Randomized Controlled Trial
Zhang Z, Garzotto M, Davis EW, Mori M, Stoller WA, Farris PE, Wong CP, Beaver LM, Thomas GV, Williams DE, Dashwood RH, Hendrix DA, Ho E, Shannon J
Nutrition and cancer · 67 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Universidad u hospital
- Oregon Agricultural Experimental Station, Hatch Funds
- Gobierno
- NCI NIH HHS
- Gobierno
- National Institute of Health
- Sin clasificar
- Clinical Trial Registration: clinicaltrials.gov identifier
- Subvenciones
- National Cancer Institute (P01 CA090890)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2019-06-01 · Nutr Cancer · vol. 72 · número 1 · págs. 74–87
- Editorial
- Routledge
- Citado
- 83 citas · más que el 88% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 48 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Reproductive System and Pregnancy
- Palabras clave
- Prostate cancer, Sulforaphane, Prostate, Medicine, Internal medicine, Prostate biopsy, Cruciferous vegetables, Cancer, Oncology, Cancer research
- MeSH
- prostate, humans, brassica, prostatic neoplasms, isothiocyanates, sulfoxides, histone deacetylases, racemases and epimerases, ki-67 antigen, anticarcinogenic agents, biopsy, chemoprevention, double-blind method, biological availability, aged, middle aged, male, cyclin-dependent kinase inhibitor p21, biomarkers, tumor, vegetable products
14 autores
- Zhenzhen Zhang🇺🇸Oregon Health & Science University
- Mark G. Garzotto🇺🇸Oregon Health & Science University; Portland VA Medical Center
- Edward W. Davis🇺🇸Oregon State University
- Motomi Mori🇺🇸Oregon Health & Science University
- Wesley A. Stoller🇺🇸Oregon Health & Science University
- Paige E. Farris🇺🇸Oregon Health & Science University
- Carmen P. Wong🇺🇸Oregon State University
- Laura M. Beaver🇺🇸Oregon State University
- GEORGE V. THOMAS🇺🇸Oregon Health & Science University
- David E. J. Williams🇺🇸Oregon State University
- Roderick H. Dashwood
- David A. Hendrix🇺🇸Oregon State University
- Emily H. Ho🇺🇸Oregon State University; Oregon Health & Science University
- Jackilen Shannon🇺🇸 · autor de correspondenciaOregon Health & Science University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Previous studies suggest compounds such as sulforaphane (SFN) derived from cruciferous vegetables may prevent prostate cancer development and progression. This study evaluated the effect of broccoli sprout extract (BSE) supplementation on blood histone deacetylase (HDAC) activity, prostate RNA gene expression, and tissue biomarkers (histone H3 lysine 18 acetylation (H3K18ac), HDAC3, HDAC6, Ki67, and p21). A total of 98 men scheduled for prostate biopsy were allocated into either BSE (200 µmol daily) or a placebo in our double-blind, randomized controlled trial. We used nonparametric tests to evaluate the differences of blood HDAC activity and prostate tissue immunohistochemistry biomarkers between treatment groups. Further, we performed RNA-Seq analysis on the prostate biopsies and identified 40 differentially expressed genes correlated with BSE treatment, including downregulation of two genes previously implicated in prostate cancer development, AMACR and ARLNC1. Although urine and plasma SFN isothiocyanates and individual SFN metabolites were statistically higher in the treatment group, our results did not show a significant difference in HDAC activity or prostate tissue biomarkers. This study indicates BSE supplementation correlates with changes in gene expression but not with several other prostate cancer biomarkers. More research is required to fully understand the chemopreventive effects of BSE supplementation on prostate cancer.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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