Low pre-exercise muscle glycogen availability offsets the effect of post-exercise cold water immersion in augmenting PGC-1α gene expression
Allan R, Sharples AP, Cocks M, Drust B, Dutton J, Dugdale HF, Mawhinney C, Clucas A, Hawkins W, Morton JP, Gregson W
Physiological reports · 4 citas
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- Ensayo controlado aleatorizado (indexado por PubMed)
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- Financiación no declarada
Publicación
- Publicado
- 2019-06-01 · Physiol Rep · vol. 7 · número 11 · pág. e14082
- Editorial
- Wiley
- Citado
- 8 citas · más que el 75% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 37 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Exercise and Physiological Responses · Cardiovascular and exercise physiology · Sports Performance and Training
- Palabras clave
- cold water immersion, PGC-1α, glycogen depletion, high-intensity cycling, AMPK signaling, mitochondrial biogenesis, post-exercise recovery, beta-adrenergic signaling, skeletal muscle gene expression
- MeSH
- muscle, skeletal, humans, glycogen, rna, messenger, exercise, cross-over studies, gene expression, adult, male, cold temperature, young adult, peroxisome proliferator-activated receptor gamma coactivator 1-alpha
11 autores
- Robert Allan🇬🇧 · autor de correspondenciaUniversity of Lancashire; Liverpool John Moores University
- Adam Philip Sharples🇬🇧Keele University; Liverpool John Moores University
- Matthew S. Cocks🇬🇧Liverpool John Moores University
- Barry Drust🇬🇧Liverpool John Moores University
- John J Dutton🇬🇧University of East Anglia
- Hannah F. Dugdale🇬🇧University of Oxford; Liverpool John Moores University; Medical Research Council
- Chris Mawhinney🇹🇭🇬🇧Mahidol University; Liverpool John Moores University
- Angela Clucas🇬🇧Liverpool John Moores University
- Will C. Hawkins🇬🇧Liverpool John Moores University
- James Peter Morton🇬🇧Liverpool John Moores University
- Warren A. Gregson🇬🇧Liverpool John Moores University
Resumen
El texto original del estudio, en el idioma en que se publicó.
We assessed the effects of post-exercise cold-water immersion (CWI) in modulating PGC-1α mRNA expression in response to exercise commenced with low muscle glycogen availability. In a randomized repeated-measures design, nine recreationally active males completed an acute two-legged high-intensity cycling protocol (8 × 5 min at 82.5% peak power output) followed by 10 min of two-legged post-exercise CWI (8°C) or control conditions (CON). During each trial, one limb commenced exercise with low (LOW: -1 dw) or very low (VLOW: -1 dw) pre-exercise glycogen concentration, achieved via completion of a one-legged glycogen depletion protocol undertaken the evening prior. Exercise increased (P < 0.05) PGC-1α mRNA at 3 h post-exercise. Very low muscle glycogen attenuated the increase in PGC-1α mRNA expression compared with the LOW limbs in both the control (CON VLOW ~3.6-fold vs. CON LOW ~5.6-fold: P = 0.023, ES 1.22 Large) and CWI conditions (CWI VLOW ~2.4-fold vs. CWI LOW ~8.0 fold: P = 0.019, ES 1.43 Large). Furthermore, PGC-1α mRNA expression in the CWI-LOW trial was not significantly different to the CON LOW limb (P = 0.281, ES 0.67 Moderate). Data demonstrate that the previously reported effects of post-exercise CWI on PGC-1α mRNA expression (as regulated systemically via β-adrenergic mediated cell signaling) are offset in those conditions in which local stressors (i.e., high-intensity exercise and low muscle glycogen availability) have already sufficiently activated the AMPK-PGC-1α signaling axis. Additionally, data suggest that commencing exercise with very low muscle glycogen availability attenuates PGC-1α signaling.
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