Associations Between Linoleic Acid Intake and Incident Type 2 Diabetes Among U.S. Men and Women
Zong G, Liu G, Willett WC, Wanders AJ, Alssema M, Zock PL, Hu FB, Sun Q
Diabetes care · 49 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Chinese Academy of Sciences
- Gobierno
- National Institutes of Health
- Gobierno
- National Key Research and Development Program of China
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NIEHS NIH HHS
- Gobierno
- NCI NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Cancer Institute (U01 CA167552); National Institute of Diabetes and Digestive and Kidney Diseases (P30DK046200); National Cancer Institute (UM1 CA186107); National Institute of Environmental Health Sciences (R01ES022981); National Heart, Lung, and Blood Institute (R01 HL035464); National Cancer Institute (U01 CA176726); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK112940); National Cancer Institute (UM1-CA-167552); National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK058845); National Cancer Institute (UM1 CA176726); National Institute of Environmental Health Sciences (R01 ES021372); National Institutes of Health (HL-035464); National Institutes of Health (DK46200); National Institutes of Health (ES022981); National Institutes of Health (P30-DK46200); National Institutes of Health (CA176726); National Institutes of Health (ES021372); National Institutes of Health (DK112940); National Institutes of Health (CA-167552); National Institutes of Health (CA186107); National Institutes of Health (DK58845)
Según 11 financiadores declarados.
Publicación
- Publicado
- 2019-06-10 · Diabetes Care · vol. 42 · número 8 · págs. 1406–1413
- Editorial
- American Diabetes Association
- Citado
- 79 citas · más que el 96% de estudios similares · 4.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Diet, Metabolism, and Disease
- Palabras clave
- Medicine, Type 2 diabetes, Polyunsaturated fatty acid, Diabetes mellitus, Linoleic acid, Hazard ratio, Prospective cohort study, Lower risk, Nurses' Health Study, Cohort study, Internal medicine, Polyunsaturated fat, Endocrinology, Confidence interval, Saturated fat, Fatty acid, Cholesterol, Biology, Biochemistry
- MeSH
- humans, diabetes mellitus, type 2, dietary fats, linoleic acids, trans fatty acids, diet, diet surveys, incidence, proportional hazards models, risk factors, follow-up studies, prospective studies, adult, middle aged, female, male
8 autores
- Geng Zong🇺🇸🇨🇳Harvard University; Shanghai Institute of Nutrition and Health; Shanghai Institutes for Biological Sciences; University of Chinese Academy of Sciences
- Gang Liu🇺🇸Harvard University
- Walter Churchill Willett🇺🇸Brigham and Women's Hospital; Harvard University
- Anne J. Wanders🇳🇱Unilever (Netherlands)
- Marjan Alssema🇳🇱Unilever (Netherlands); Amsterdam UMC Location Vrije Universiteit Amsterdam
- Peter L. Zock🇳🇱Unilever (Netherlands)
- Frank B. Hu🇺🇸Brigham and Women's Hospital; Harvard University
- Qi Sun🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To investigate the association between intakes of n-6 polyunsaturated fatty acids (PUFAs) and type 2 diabetes risk in three prospective cohort studies of U.S. men and women.
Research design and methods
We followed 83,648 women from the Nurses' Health Study (NHS) (1980-2012), 88,610 women from NHSII (1991-2013), and 41,771 men from the Health Professionals Follow-Up Study (HPFS) (1986-2012). Dietary data were collected every 2-4 years by using validated food-frequency questionnaires. Self-reported incident diabetes, identified biennially, was confirmed by using a validated supplementary questionnaire.
Results
During 4.93 million person-years of follow-up, 18,442 type 2 diabetes cases were documented. Dietary n-6 PUFAs accounted for 4.4-6.8% of total energy, on average, and consisted primarily of linoleic acid (LA) (≥98%). In multivariate-adjusted models, hazard ratios (95% CIs) of type 2 diabetes risk comparing extreme n-6 PUFA quintiles (highest vs. lowest) were 0.91 (0.85, 0.96) (P trend = 0.002) for total n-6 PUFAs and 0.92 (0.87, 0.98) (P trend = 0.01) for LA. In an isocaloric substitution model, diabetes risk was 14% (95% CI 5%, 21%) (P = 0.002) lower when LA isocalorically replaced saturated fats (5% of energy), 17% (95% CI 9%, 24%) (P trans fats (2% of energy), or 9% (95% CI 17%, 0.1%) (P = 0.047) lower for carbohydrates (5% of energy). Replacing n-3 PUFAs or monounsaturated fats with LA was not significantly associated with type 2 diabetes risk.
Conclusions
Our study provides additional evidence that LA intake is inversely associated with risk of type 2 diabetes, especially when replacing saturated fatty acids, trans fats, or carbohydrates.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.