Cold-pressed Canola Oil Reduces Hepatic Steatosis by Modulating Oxidative Stress and Lipid Metabolism in KM Mice Compared with Refined Bleached Deodorized Canola Oil
Zhou YJ, Chang YN, You JQ, Li SZ, Zhuang W, Cao CJ
Journal of food science · 6 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Qinghai Science and Technology Department Grant
Según 1 financiador declarado.
Publicación
- Publicado
- 2019-06-10 · J Food Sci · vol. 84 · número 7 · págs. 1900–1908
- Editorial
- Wiley
- Citado
- 15 citas · más que el 78% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 48 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Cholesterol and Lipid Metabolism · Diet and metabolism studies
- Palabras clave
- Canola, Steatosis, Lipid metabolism, Chemistry, Fatty acid synthase, Oxidative stress, Hyperlipidemia, Biochemistry, Sterol, Food science, Cholesterol, Endocrinology, Internal medicine, Biology, Medicine, Diabetes mellitus
- MeSH
- liver, animals, humans, mice, fatty liver, insulin resistance, cholesterol, acetyl-coa carboxylase, fatty acids, triglycerides, phospholipids, ppar alpha, oxidative stress, male, lipogenesis, lipid metabolism, sterol regulatory element binding protein 1, fatty acid synthases, rapeseed oil
6 autores
- Yingjun Zhou🇨🇳East China University of Science and Technology
- Yaning Chang🇨🇳 · autor de correspondenciaEast China University of Science and Technology
- Jiaqi You🇨🇳East China University of Science and Technology
- Sui‐Zi Li🇨🇳East China University of Science and Technology
- Wei Zhuang🇨🇳East China University of Science and Technology
- Cheng‐Jia Cao🇨🇳East China University of Science and Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
The quality of canola oil is affected by different extraction methods. The effect of cold-pressed canola oil (CPCO) diet and traditional refined bleached deodorized canola oil (RBDCO) diet on lipid accumulation and hepatic steatosis in mice were investigated. The body weight, peroxisome proliferator-activated receptor-α concentration, serum lipid profile, insulin sensitivity, and oxidative stress were increased in mice fed with CPCO diet, which had higher unsaturated fatty acid, tocopherols, phytosterols, and phospholipids but lower saturated fatty acid than RBDCO, after 12 weeks,. Moreover, CPCO significantly increased tocopherols and phytosterols content in liver and reduced liver cholesterol contents and lipid vacuoles accumulation than RBDCO. Also, serum proinflammatory cytokines, 3-hydroxy-3-methylglutary coenzyme A reductase expression level, lipogenic enzymes, and transcriptional factors such as sterol regulatory element-binding proteins 1c, acetyl-CoA carboxylase, and fatty acid synthase in the liver were also markedly downregulated from CPCO diet mice. Overall, CPCO can reduce lipid accumulation and hepatic steatosis by regulating oxidative stress and lipid metabolism in Kun Ming mice compared with RBDCO. PRACTICAL APPLICATION: The results suggested that more bioactive components were contained in cold-pressed canola oil (CPCO) rather than refined bleached deodorized canola oil (RBDCO). CPCO could lower the risk of obesity and hyperlipidemia, reduce lipid accumulation, and prevent hepatic steatosis. It could be considered as a kind of better edible oil than RBDCO.
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