Examining tumor modulating effects of photobiomodulation therapy on head and neck squamous cell carcinomas
Silveira FM, Paglioni MP, Marques MM, Santos-Silva AR, Migliorati CA, Arany P, Martins MD
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 26 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
Según 2 financiadores declarados.
Publicación
- Publicado
- 2019-06-10 · Photochem Photobiol Sci · vol. 18 · número 7 · págs. 1621–1637
- Editorial
- Springer Science+Business Media
- Citado
- 40 citas · más que el 93% de estudios similares · 3.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Photodynamic Therapy Research Studies · Head and Neck Cancer Studies
- Palabras clave
- low-level laser therapy, head and neck squamous cell carcinoma, oral squamous cell carcinoma, tumor cell proliferation, cell viability, oral mucositis, radiotherapy complications, tumor progression
- MeSH
- humans, head and neck neoplasms, cell proliferation, databases, factual, lasers, gas, low-level light therapy, squamous cell carcinoma of head and neck
7 autores
- Felipe Martins Silveira🇧🇷Universidade Estadual de Campinas (UNICAMP)
- Mariana de Pauli Paglioni🇧🇷Universidade Estadual de Campinas (UNICAMP)
- Márcia Martins Marques🇧🇷Universidade de São Paulo
- Alan Roger Santos‐Silva🇧🇷Universidade Estadual de Campinas (UNICAMP)
- Cesar Augusto Migliorati🇺🇸University of Florida
- Praveen Ravindra Arany🇺🇸University at Buffalo, State University of New York
- Manoela Domingues Martins🇧🇷 · autor de correspondenciaUniversidade Federal do Rio Grande do Sul; Universidade Estadual de Campinas (UNICAMP)
Resumen
El texto original del estudio, en el idioma en que se publicó.
Photobiomodulation (PBM) therapy is an effective method for preventing and managing oral mucositis (OM) in head and neck squamous cell carcinoma (HNSCC) patients undergoing radiotherapy alone or in combination with chemotherapy. However, the potential effects of PBM therapy on premalignant and malignant cells eventually present in the treatment site are yet unknown. The aim of this systematic review was to analyze the effects of PBM therapy on HNSCC. A literature search was conducted in four indexed databases as follows: MEDLINE/PubMed, EMBASE, Web of Science, and Scopus. The databases were reviewed for papers published up to and including in October 2018. In vitro and in vivo studies that investigated the effects of PBM therapy on HNSCC were selected. From the 852 initially gathered studies, 15 met the inclusion criteria (13 in vitro and 2 in vivo). Only three in vitro studies were noted to have a low risk of bias. The included data demonstrated wide variations of study designs, PBM therapy protocols, and study outcomes. Cell proliferation and viability were the primary evaluation outcome in the in vitro studies. Of the 13 in vitro studies, seven noted a positive effect of PBM therapy on inhibiting or preventing an effect on HNSCC tumor cells, while six studies saw increased proliferation. One in vivo study reported increased oral SCC (OSCC) progression, while the other observed reduced tumor progression. Overall, the data from the studies included in the present systematic review do not support a clear conclusion about the effects of PBM therapy on HNSCC cells.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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