Effects of low level laser therapy in cancer cells-a systematic review of the literature
da Silva JL, Silva-de-Oliveira AFS, Andraus RAC, Maia LP
Lasers in medical science · 20 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2019-06-17 · Lasers Med Sci · vol. 35 · número 3 · págs. 523–529
- Editorial
- Springer Science+Business Media
- Citado
- 30 citas · más que el 70% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 22 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Photodynamic Therapy Research Studies · Biofield Effects and Biophysics
- Palabras clave
- low-level laser therapy, cancer cells, cell viability, apoptosis, laser wavelength, laser irradiation parameters, cell proliferation, inflammatory mediators, gene expression
- MeSH
- humans, neoplasms, apoptosis, cell proliferation, cell survival, low-level light therapy
4 autores
- Jéssica Lúcio da Silva🇧🇷Universidade Norte do Paraná
- Ana Flávia Spadaccini Silva-de-Oliveira🇧🇷Universidade Norte do Paraná
- Rodrigo Antônio Carvalho Andraus🇧🇷Universidade Norte do Paraná
- Luciana Prado Maia🇧🇷 · autor de correspondenciaUniversidade Norte do Paraná
Resumen
El texto original del estudio, en el idioma en que se publicó.
The aim of the present study was to conduct a systematic review regarding the use of photobiomodulation (PBM) therapy in tumoral cells, addressing the different types of lasers and parameters used. An electronic search was performed in PubMed/MEDLINE, Cochrane Library, and EMBASE databases. The inclusion criteria were being an in vitro study, with tumoral cells, and have at least one group of treatment with low-power laser and a control group (without treatment). Were excluded studies that used only non-carcinogenic cells, in vivo studies, studies that used high-power laser or the association with photosensitizers. The primary outcome evaluated was the cellular viability, and the secondary outcomes were the apoptosis rate and gene and inflammatory mediators' expression. Nineteen studies were identified among the lists of citations of studies that met the exclusion/inclusion criteria. There is a wide divergence regarding the wavelengths and doses used, as well as the type of laser, and each variation leads to different results, with some studies showing an increase in cell proliferation, while other studies showed a decrease. It is possible to suggest that PBM can be used in cancerous lesions in order to decrease the proliferation of these cells depending on the parameters used; however, the lack of standardization of laser irradiation protocols for in vitro investigations does not allow the establishment of ideal parameters for this purpose. Therefore, PBM should be used with caution in cancer patients until more studies are performed.
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