Antimicrobial Resistance and Virulence Genes in Enterococcus faecium and Enterococcus faecalis from Humans and Retail Red Meat
Golob M, Pate M, Kušar D, Dermota U, Avberšek J, Papić B, Zdovc I
BioMed research international · 50 citas
Etiquetas de revisión
Solo mecanismosSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Javna Agencija za Raziskovalno Dejavnost RS
- Subvenciones
- Javna Agencija za Raziskovalno Dejavnost RS (No. P4-0092); Javna Agencija za Raziskovalno Dejavnost RS (P4-0092)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-05-09 · Biomed Res Int · vol. 2019 · págs. 1–12
- Editorial
- Hindawi Publishing Corporation
- Citado
- 90 citas · más que el 97% de estudios similares · 7.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 75 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Probiotics and Fermented Foods · Antimicrobial Resistance in Staphylococcus · Oral microbiology and periodontitis research
- Palabras clave
- Virulence, Enterococcus faecalis, Enterococcus faecium, Teicoplanin, Biology, Microbiology, Antimicrobial, Broth microdilution, Linezolid, Antibiotic resistance, Enterococcus, Multiple drug resistance, Drug resistance, Gene, Vancomycin, Minimum inhibitory concentration, Antibiotics, Staphylococcus aureus, Bacteria, Genetics
- MeSH
- animals, humans, enterococcus faecalis, enterococcus faecium, anti-bacterial agents, food microbiology, drug resistance, bacterial, slovenia, pork meat
7 autores
- Majda Golob🇸🇮 · autor de correspondenciaUniversity of Ljubljana
- Mateja Pate🇸🇮University of Ljubljana
- Darja Kušar🇸🇮University of Ljubljana
- Urška Dermota🇸🇮National Laboratory of Health, Environment and Food
- Jana Avberšek🇸🇮University of Ljubljana
- Bojan Papić🇸🇮University of Ljubljana
- Irena Zdovc🇸🇮University of Ljubljana
Resumen
El texto original del estudio, en el idioma en que se publicó.
The emergence of antimicrobial-resistant and virulent enterococci is a major public health concern. While enterococci are commonly found in food of animal origin, the knowledge on their zoonotic potential is limited. The aim of this study was to determine and compare the antimicrobial susceptibility and virulence traits of Enterococcus faecalis and Enterococcus faecium isolates from human clinical specimens and retail red meat in Slovenia. A total of 242 isolates were investigated: 101 from humans (71 E. faecalis, 30 E. faecium) and 141 from fresh beef and pork (120 E. faecalis, 21 E. faecium). The susceptibility to 12 antimicrobials was tested using a broth microdilution method, and the presence of seven common virulence genes was investigated using PCR. In both species, the distribution of several resistance phenotypes and virulence genes was disparate for isolates of different origin. All isolates were susceptible to daptomycin, linezolid, teicoplanin, and vancomycin. In both species, the susceptibility to antimicrobials was strongly associated with a food origin and the multidrug resistance, observed in 29.6% of E. faecalis and 73.3% E. faecium clinical isolates, with a clinical origin (Fisher's exact test). Among meat isolates, in total 66.0% of E. faecalis and E. faecium isolates were susceptible to all antimicrobials tested and 32.6% were resistant to either one or two antimicrobials. In E. faecalis, several virulence genes were significantly associated with a clinical origin; the most common (31.0%) gene pattern included all the tested genes except hyl. In meat isolates, the virulence genes were detected in E. faecalis only and the most common pattern included ace, efaA, and gelE (32.5%), of which gelE showed a statistically significant association with a clinical origin. These results emphasize the importance of E. faecalis in red meat as a reservoir of virulence genes involved in its persistence and human infections with reported severe outcomes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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