Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption
Villanueva JE, Livelo C, Trujillo AS, Chandran S, Woodworth B, Andrade L, Le HD, Manor U, Panda S, Melkani GC
Nature communications · 130 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Health and Human Services
- Universidad u hospital
- San Diego State University
- Organización sin fines de lucro
- Waitt Foundation
- Gobierno
- National Institutes of Health
- Gobierno
- Medical Research Council
- Gobierno
- National Institute on Aging
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Institute of Neurological Disorders and Stroke
- Gobierno
- NCI NIH HHS
- Gobierno
- NIDDK NIH HHS
- Gobierno
- U.S. Department of Health & Human Services | NIH | National Institute on Aging
- Gobierno
- NIA NIH HHS
- Gobierno
- NINDS NIH HHS
- Subvenciones
- National Cancer Institute (CA014195); National Institute on Aging (R01 AG049494); National Institute on Aging (R56 AG049494); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK115214); National Institute of Neurological Disorders and Stroke (P30 NS072031); National Institute of Neurological Disorders and Stroke (NS072031); National Cancer Institute (P30 CA-014195); U.S. Department of Health and Human Services (AG049494); Waitt Foundation (CA014195); National Institutes of Health (2r56ag049494-06a1); National Institute on Aging (AG049494); Medical Research Council (MR/L023784/1); National Institutes of Health (CA014195); National Institutes of Health (NS072031); National Institutes of Health (DK115214); National Institutes of Health (AG049494)
Según 14 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-06-20 · Nat Commun · vol. 10 · número 1 · pág. 2700
- Editorial
- Nature Portfolio
- Citado
- 160 citas · más que el 98% de estudios similares · 8.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 75 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Circadian rhythm and melatonin · Genetics, Aging, and Longevity in Model Organisms
- Palabras clave
- Insulin resistance, Circadian rhythm, Skeletal muscle, Endocrinology, Biology, Internal medicine, Obesity, Medicine
- MeSH
- sarcomeres, muscle, skeletal, animals, animals, genetically modified, humans, drosophila melanogaster, chronobiology disorders, obesity, disease models, animal, treatment outcome, fasting, energy metabolism, circadian rhythm, female, male, diet, high-fat, shift work schedule, metabolic syndrome
10 autores
- Jesús E. Villanueva🇺🇸San Diego State University
- Christopher Livelo🇺🇸San Diego State University
- Adriana S. Trujillo🇺🇸San Diego State University
- Sahaana Chandran🇺🇸San Diego State University
- Brendon Woodworth🇺🇸San Diego State University
- Leo Andrade🇺🇸Salk Institute for Biological Studies
- Hiep D. Le🇺🇸Salk Institute for Biological Studies
- Uri Manor🇺🇸Salk Institute for Biological Studies
- Satchidananda Panda🇺🇸Salk Institute for Biological Studies
- Girish C. Melkani🇺🇸 · autor de correspondenciaSalk Institute for Biological Studies; San Diego State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Pathological obesity can result from genetic predisposition, obesogenic diet, and circadian rhythm disruption. Obesity compromises function of muscle, which accounts for a majority of body mass. Behavioral intervention that can counteract obesity arising from genetic, diet or circadian disruption and can improve muscle function holds untapped potential to combat the obesity epidemic. Here we show that Drosophila melanogaster (fruit fly) subject to obesogenic challenges exhibits metabolic disease phenotypes in skeletal muscle; sarcomere disorganization, mitochondrial deformation, upregulation of Phospho-AKT level, aberrant intramuscular lipid infiltration, and insulin resistance. Imposing time-restricted feeding (TRF) paradigm in which flies were fed for 12 h during the day counteracts obesity-induced dysmetabolism and improves muscle performance by suppressing intramuscular fat deposits, Phospho-AKT level, mitochondrial aberrations, and markers of insulin resistance. Importantly, TRF was effective even in an irregular lighting schedule mimicking shiftwork. Hence, TRF is an effective dietary intervention for combating metabolic dysfunction arising from multiple causes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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