Walnut-Derived Peptide PW5 Ameliorates Cognitive Impairments and Alters Gut Microbiota in APP/PS1 Transgenic Mice
Wang M, Amakye WK, Guo L, Gong C, Zhao Y, Yao M, Ren J
Molecular nutrition & food research · 61 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Ministry of Education of the People's Republic of China
- Gobierno
- Ministry of Education of the People's Republic of China
- Subvenciones
- Ministry of Education of the People's Republic of China (B17018); National Natural Science Foundation of China (31671804)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2019-06-25 · Mol Nutr Food Res · vol. 63 · número 18 · pág. e1900326
- Editorial
- Wiley
- Citado
- 99 citas · más que el 94% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- De pago
- Áreas de investigación
- Protein Hydrolysis and Bioactive Peptides · Proteins in Food Systems · Nuts composition and effects
- Palabras clave
- Gut flora, Pharmacology, Firmicutes, In vivo, Biology, Chemistry, Biochemistry, Biotechnology
- MeSH
- hippocampus, animals, mice, transgenic, humans, juglans, alzheimer disease, fatty acids, volatile, peptides, neurotransmitter agents, maze learning, amyloid beta-peptides, hek293 cells, gastrointestinal microbiome, cognitive dysfunction, plant proteins, dietary
7 autores
- Min Wang🇨🇳South China University of Technology
- William Kwame Amakye🇨🇳South China University of Technology
- Lu Cun Guo🇨🇳South China University of Technology
- Congcong Gong🇨🇳South China University of Technology
- Yuanhui Zhao🇨🇳Ocean University of China
- Maojin Yao🇺🇸University of Virginia
- Jiaoyan Ren🇨🇳 · autor de correspondenciaSouth China University of Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Scope
Decreasing β-amyloid (Aβ) accumulation is of significance in finding therapeutic candidates for cognitive impairments in Alzheimer's disease (AD). The aim of this study is to investigate the potency of the active components of walnut protein in decreasing Aβ aggregation and ameliorating cognitive impairments.
Methods and results
Cell model of intracellular Aβ42 aggregation is used to explore the active ingredients in walnut protein hydrolysate (WPH). A bioactive peptide (Pro-Pro-Lys-Asn-Trp, PW5) with great anti-Aβ42 aggregation activity identified from the WPH is synthesized for in vitro and in vivo experiments. Using classic APP/PS1 mouse model, it is validated that PW5 exerts its effects on cognitive improvement through reducing Aβ plaques accumulation. Moreover, metabolomic analysis reveals that serum norepinephrine (NE) and isovalerate levels are significantly increased in response to PW5 intervention, with decreased serum levels of acetylcholine (AChe) and valerate, compared with the vehicle-treated APP/PS1 mice. PW5 feeding also improves gut dysbiosis in APP/PS1 transgenic mice by increasing the relative abundance of Firmicutes and decreasing Proteobacteria and Verrucomicrobia as displayed by 16s rRNA analyses.
Conclusions
These promising results support the utilization of peptide PW5 as an active ingredient in functional foods or potential drug candidate for the prevention and/or treatment of AD.
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