Financiado en parte por AlzChem AG
Creatine Supplementation (3 g/d) and Bone Health in Older Women: A 2-Year, Randomized, Placebo-Controlled Trial
Sales LP, Pinto AJ, Rodrigues SF, Alvarenga JC, Gonçalves N, Sampaio-Barros MM, Benatti FB, Gualano B, Rodrigues Pereira RM
The journals of gerontology. Series A, Biological sciences and medical sciences · 27 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Empresa
- AlzChem AG
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior
- Subvenciones
- Fundação de Amparo à Pesquisa do Estado de São Paulo (15/26937-4); Fundação de Amparo à Pesquisa do Estado de São Paulo (15/14698-5)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2019-06-29 · J Gerontol A Biol Sci Med Sci · vol. 75 · número 5 · págs. 931–938
- Editorial
- Oxford University Press
- Citado
- 39 citas · más que el 83% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Nutrition and Health in Aging · Bone health and osteoporosis research
- Palabras clave
- Creatine, Osteopenia, Medicine, Lean body mass, Bone mineral, Placebo, Femoral neck, Osteoporosis, Randomized controlled trial, Population, Creatine Monohydrate, Internal medicine, Physical therapy, Body weight
- MeSH
- humans, bone diseases, metabolic, osteoporosis, creatine, absorptiometry, photon, double-blind method, accidental falls, postmenopause, bone density, aged, middle aged, brazil, female, fractures, bone, muscle strength
9 autores
- Lucas Peixoto Sales🇧🇷Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Ana Jéssica Pinto🇧🇷Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Samara Ferrari Rodrigues🇧🇷Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Jackeline Couto Alvarenga🇧🇷Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Natália Gonçalves🇧🇷Centrus Diagnósticos por Imagem
- Marília M Sampaio-Barros🇧🇷Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Fabiana Braga Benatti🇧🇷Universidade Estadual de Campinas (UNICAMP)
- Bruno Gualano🇧🇷 · autor de correspondenciaHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Rosa Maria Rodrigues Pereira🇧🇷Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Creatine supplementation could be a nonexpensive, safe, and effective dietary intervention to counteract bone loss. The aim of this study was to investigate whether long-term creatine supplementation can improve bone health in older, postmenopausal women.
Methods
A double-blind, placebo-controlled, parallel-group, randomized trial was conducted between November 2011 and December 2017 in Sao Paulo, Brazil. Two hundred postmenopausal women with osteopenia were randomly allocated to receive either creatine monohydrate (3 g/d) or placebo for 2 years. At baseline and after 12 and 24 months, we assessed areal bone mineral density (aBMD; primary outcome), lean and fat mass (through dual X-ray absorptiometry), volumetric BMD and bone microarchitecture parameters, biochemical bone markers, physical function and strength, and the number of falls and fractures. Possible adverse effects were self-reported.
Results
Lumbar spine (p .050). Bone markers, microarchitecture parameters, and the number of falls/fractures were not changed with creatine (all p > .050). Lean mass and appendicular skeletal muscle mass increased throughout the intervention (p < .001), with no additive effect of creatine (p = .731 and p = .397, respectively). Creatine did not affect health-related laboratory parameters.
Conclusion
Creatine supplementation more than 2 years did not improve bone health in older, postmenopausal women with osteopenia, nor did it affect lean mass or muscle function in this population. This refutes the long-lasting notion that this dietary supplement alone has osteogenic or anabolic properties in the long run.
Clinical trial registry
Clinicaltrials.gov: NCT: 01472393.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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