Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China
Chen JG, Johnson J, Egner P, Ng D, Zhu J, Wang JB, Xue XF, Sun Y, Zhang YH, Lu LL, Chen YS, Wu Y, Zhu YR, Carmella S, Hecht S, Jacobson L, Muñoz A, Kensler K, Rule A, Fahey J, Kensler T, Groopman J
The American journal of clinical nutrition · 34 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Biomarcadores de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (R01 CA190610); National Cancer Institute (R35CA197222); National Institutes of Health (R01 CA190610)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2019-05-27 · Am J Clin Nutr · vol. 110 · número 3 · págs. 675–684
- Editorial
- Elsevier BV
- Citado
- 43 citas · más que el 78% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 54 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Glutathione Transferases and Polymorphisms · Phytochemicals and Antioxidant Activities
- Palabras clave
- sulforaphane, S-phenylmercapturic acid, urinary biomarkers, glutathione conjugation, air pollution exposure, dose-dependent effects, dietary intervention
- MeSH
- humans, brassica, benzene, isothiocyanates, sulfoxides, air pollutants, dose-response relationship, drug, beverages, middle aged, china, female, male, inactivation, metabolic, seedlings
22 autores
- Jianguo Chen🇨🇳Qidong Liver Cancer Prevention Research
- Jamie Johnson🇺🇸Johns Hopkins University
- Patricia A. Egner🇺🇸Johns Hopkins University
- Derek K. Ng🇺🇸Johns Hopkins University
- Jian Zhu🇨🇳Qidong Liver Cancer Prevention Research
- Jin-Bing Wang🇨🇳Qidong Liver Cancer Prevention Research
- Xuefeng Xue🇨🇳Qidong Liver Cancer Prevention Research
- Yan Sun🇨🇳Qidong Liver Cancer Prevention Research
- Yong-Hui Zhang🇨🇳Qidong Liver Cancer Prevention Research
- Ling-ling Lu🇨🇳Qidong Liver Cancer Prevention Research
- Yong-Sheng Chen🇨🇳Qidong Liver Cancer Prevention Research
- Yan Wu🇨🇳Qidong Liver Cancer Prevention Research
- Yuan-Rong Zhu🇨🇳Qidong Liver Cancer Prevention Research
- Steven G. Carmella🇺🇸University of Minnesota; Masonic Cancer Center
- Stephen S. Hecht🇺🇸University of Minnesota; Masonic Cancer Center
- Lisa P. Jacobson🇺🇸Johns Hopkins University
- Álvaro Muñoz🇺🇸Johns Hopkins University
- Kevin H. Kensler🇺🇸Harvard University
- Ana María Rule🇺🇸Johns Hopkins University
- Jed W. Fahey🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Thomas W. Kensler🇺🇸Harvard University; Johns Hopkins University; Johns Hopkins Medicine; Fred Hutch Cancer Center
- John D. Groopman🇺🇸Johns Hopkins University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Airborne pollutants have collectively been classified as a known human carcinogen and, more broadly, affect the health of hundreds of millions of people worldwide. Benzene is a frequent component of air pollution, and strategies to protect individuals against unavoidable exposure to this and other airborne carcinogens could improve the public's health. Earlier clinical trials in Qidong, China, demonstrated efficacy in enhancing the detoxication of benzene using a broccoli sprout beverage.
Objectives
A randomized, placebo-controlled, multidose trial of a broccoli sprout beverage was designed to determine the lowest effective concentration that enhances benzene detoxication adjudged by enhanced excretion of the urinary biomarker, S-phenylmercapturic acid (SPMA).
Methods
Following informed consent, 170 subjects were randomly assigned in 5 blocks of 34 each to drink either a placebo beverage (n = 55) or 1 of 3 graded concentrations of a broccoli sprout beverage [full (n = 25), one-half (n = 35), and one-fifth (n = 55)] for 10 consecutive days. Concentrations of SPMA arising through induced benzene conjugation with glutathione were quantified by MS in sequential 12-h overnight urine collections during the intervention.
Results
MS was also used to quantify urinary sulforaphane metabolites in each dosing regimen that resulted in a median 24-h urinary output of 24.6, 10.3, and 4.3 µmol, respectively, confirming a dose-dependent de-escalation of the inducing principle within the beverage. A statistically significant increase in benzene mercapturic acids in urine was found for the high-dose group (+63.2%) during the 10-d period. The one-half dose (+11.3%) and one-fifth dose groups (-6.4%) were not significantly different from placebo controls.
Conclusions
An intervention with a broccoli sprout beverage enhanced the detoxication of benzene, an important airborne pollutant, when dosed at a concentration evoking a urinary elimination of ∼25 µmol sulforaphane metabolites per day, and it portends a practical and frugal population-based strategy to attenuate associated long-term health risks of air pollution. This trial was registered at clinicaltrials.gov as NCT02656420.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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