The benefit of a ceramide-linoleic acid-containing moisturizer as an adjunctive therapy for a set of xerotic dermatoses
Yang Q, Liu M, Li X, Zheng J
Dermatologic therapy · 12 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- H2020 European Research Council
- Subvenciones
- National Natural Science Foundation of China (81830095); National Natural Science Foundation of China (81673056)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2019-07-05 · Dermatol Ther · vol. 32 · número 4 · pág. e13017
- Editorial
- Wiley
- Citado
- 22 citas · más que el 88% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 64 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dermatology and Skin Diseases · Contact Dermatitis and Allergies · Advancements in Transdermal Drug Delivery
- Palabras clave
- atopic dermatitis, chronic eczema, topical corticosteroids, mometasone furoate, epidermal permeability barrier, transepidermal water loss, pruritus, adjunctive therapy, skin barrier repair
- MeSH
- humans, dermatitis, atopic, eczema, pruritus, ceramides, linoleic acid, dermatologic agents, emollients, glucocorticoids, treatment outcome, administration, cutaneous, severity of illness index, water loss, insensible, electric capacitance, mometasone furoate
4 autores
- Qi Yang🇨🇳Shanghai Jiao Tong University; Ruijin Hospital
- Min Liu🇨🇳Shanghai Jiao Tong University; Ruijin Hospital
- Xia Li🇨🇳 · autor de correspondenciaShanghai Jiao Tong University; Ruijin Hospital
- Jie Zheng🇨🇳Shanghai Jiao Tong University; Ruijin Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Atopic dermatitis (AD), chronic eczema, and pruritus hiemalis are a set of prevalent chronic xerotic skin disorders that share clinical features such as dryness, scales, and pruritus. A ceramide deficiency and defective epidermal functions are common in these diseases. This study was designed to assess the effect of ceramide-linoleic acid (LA-Cer)-containing moisturizer as an adjunctive therapy in the treatment of AD, chronic eczema, and pruritus hiemalis. In a 2-month study, patients with one of these three diseases were divided into two groups. The control group was treated with mometasone furoate (0.1%) cream (MF), whereas the treatment group received 0.1% MF in combination with an LA-Cer-containing moisturizer. Capacitance and transepidermal water loss were measured in normal and lesional skin, along with Eczema Assessment Severity Index and pruritus scores at Weeks 0, 2, 4, and 8. The results showed that tropical applications of an LA-Cer-containing moisturizer in combination with a topical glucocorticoid accelerated the reestablishment of epidermal permeability barrier and the amelioration of pruritus in patients with AD and pruritus hiemalis. However, it did not provide the same effect for chronic eczema. Thus, the efficacy of this combination therapy for this set of xerotic disorders requires further evaluation.
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