Effects of vitamin D supplementation on cognitive function and blood Aβ-related biomarkers in older adults with Alzheimer's disease: a randomised, double-blind, placebo-controlled trial
Jia J, Hu J, Huo X, Miao R, Zhang Y, Ma F
Journal of neurology, neurosurgery, and psychiatry · 150 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (81573148); National Natural Science Foundation of China (81874261); National Natural Science Foundation of China (81573148; 81874261)
Según 1 financiador declarado.
Publicación
- Publicado
- 2019-07-11 · J Neurol Neurosurg Psychiatry · vol. 90 · número 12 · págs. jnnp–2018
- Editorial
- BMJ
- Citado
- 149 citas · más que el 98% de estudios similares · 7.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Dementia and Cognitive Impairment Research · Alzheimer's disease research and treatments
- Palabras clave
- vitamin D supplementation, Alzheimer's disease, cognitive function, amyloid-beta, amyloid-beta 42, APP, BACE1, older adults
- MeSH
- humans, alzheimer disease, hydroxycholecalciferols, vitamins, vitamin d, amyloid beta-protein precursor, double-blind method, cognition, psychomotor performance, intelligence tests, neuropsychological tests, dietary supplements, aged, female, male, amyloid precursor protein secretases, aspartic acid endopeptidases
6 autores
- Jingya Jia🇨🇳Tianjin Medical University
- Jing Ying Hu🇨🇳Tianjin Medical University
- Xiaoxu Huo🇨🇳Tianjin Medical University
- Rujuan Miao🇨🇳Tianjin Medical University
- Yanping Zhang🇨🇳Tianjin Medical University General Hospital
- Fei Ma🇨🇳 · autor de correspondenciaTianjin Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Our study aimed to assess the effect of a 12-month vitamin D supplementation on cognitive function and amyloid beta (Aβ)-related biomarkers in subjects with Alzheimer's disease (AD). METHODS : This was a randomised, double-blind, placebo-controlled trial. 210 AD patients were randomly divided into intervention and control groups. Participants received 12-month 800 IU/day of vitamin D or starch granules as placebo. Tests of cognitive performance and Aβ-related biomarkers were measured at baseline, 6 months and 12 months. RESULTS : Repeated-measures analysis of variance showed significant improvements in plasma Aβ42, APP, BACE1, APPmRNA, BACE1mRNA (p<0.001) levels and information, arithmetic, digit span, vocabulary, block design and picture arrange scores (p<0.05) in the intervention group over the control group. According to mixed-model analysis, vitamin D group had significant increase in full scale IQ during follow-up period (p<0.001).
Conclusions
Daily oral vitamin D supplementation (800 IU/day) for 12 months may improve cognitive function and decrease Aβ-related biomarkers in elderly patients with AD. Larger scale longer term randomised trials of vitamin D are needed.
Trial registration number
ChiCTR-IIR-16009549.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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