Profile of Fatty Acids, Tocopherols, Phytosterols and Polyphenols in Mediterranean Oils (Argan Oils, Olive Oils, Milk Thistle Seed Oils and Nigella Seed Oil) and Evaluation of their Antioxidant and Cytoprotective Activities
Zarrouk A, Martine L, Grégoire S, Nury T, Meddeb W, Camus E, Badreddine A, Durand P, Namsi A, Yammine A, Nasser B, Mejri M, Bretillon L, Mackrill JJ, Cherkaoui-Malki M, Hammami M, Lizard G
Current pharmaceutical design · 55 citas
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Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2019-07-06 · Curr Pharm Des · vol. 25 · número 15 · págs. 1791–1805
- Editorial
- Bentham Science Publishers
- Citado
- 96 citas · más que el 99% de estudios similares · 13.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 84 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nigella sativa pharmacological applications · Cholesterol and Lipid Metabolism · Essential Oils and Antimicrobial Activity
- Palabras clave
- Phytosterol, Polyphenol, Hydroxytyrosol, Food science, Chemistry, Linoleic acid, Oleic acid, Fatty acid, Antioxidant, Tocopherol, Vitamin E, Biochemistry
- MeSH
- cell line, animals, humans, mice, nigella, seeds, phytosterols, fatty acids, plant oils, tocopherols, antioxidants, polyphenols, olive oil, silybum marianum
17 autores
- Amira Zarrouk🇹🇳University of Monastir
- Lucy Martine🇫🇷Centre National de la Recherche Scientifique; Université de Bourgogne; Centre des Sciences du Goût et de l'Alimentation
- Stéphane Gregoire🇫🇷Centre National de la Recherche Scientifique; Université de Bourgogne; Centre des Sciences du Goût et de l'Alimentation
- Thomas Nury🇫🇷Inserm; Université de Bourgogne
- Wiem Meddeb🇹🇳Institut Supérieur de Biotechnologie de Sfax
- Emmanuelle Camus🇫🇷Laboratoires Spiral (France)
- Asmaa Badreddine🇲🇦Université Hassan 1er
- Philippe Durand🇫🇷Laboratoires Spiral (France)
- Amira Namsi🇫🇷Inserm; Université de Bourgogne
- Aline Yammine🇫🇷Inserm; Université de Bourgogne
- Boubker Nasser🇲🇦Université Hassan 1er
- Mondher Mejri🇹🇳Institut Supérieur de Biotechnologie de Sfax
- Lionel Brétillon🇫🇷Centre National de la Recherche Scientifique; Université de Bourgogne; Centre des Sciences du Goût et de l'Alimentation
- John James Mackrill🇮🇪University College Cork
- Mustapha Cherkaoui‐Malki🇫🇷Inserm; Université de Bourgogne
- Mohamed Bassem Hammami🇹🇳University of Monastir
- Gérard Lizard🇫🇷 · autor de correspondenciaInserm; Université de Bourgogne
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The effects of vegetable oils on human health depend on their components. Therefore, their profiles of lipid nutrients and polyphenols were determined.
Objective
To establish and compare the fatty acid, tocopherol, phytosterol and polyphenol profiles of Mediterranean oils: cosmetic and dietary argan oils (AO; Morocco: Agadir, Berkane); olive oils (OO; Morocco, Spain, Tunisia); milk thistle seed oils (MTSO; Tunisia: Bizerte, Sousse, Zaghouane); nigella seed oil (NSO).
Methods
The biochemical profiles were determined by gas chromatography-flame ionization, high performance liquid chromatography and gas chromatography, coupled with mass spectrometry as required. The antioxidant and cytoprotective activities were evaluated with the KRL (Kit Radicaux Libres) and the fluorescein diacetate tests on nerve cells treated with 7-ketocholesterol (7KC).
Results
The fatty acid profile revealed high linoleic acid (C18:2 n-6) content in AO, OO, MTSO and NSO. The highest levels of oleic acid (C18:1 n-9) were found in AO and OO. The tocopherol profile showed that Agadir AO contained the highest amount of α-tocopherol, also present at high level in MTSO and Tunisian OO; Berkane AO was rich in γ-tocopherol. The phytosterol profile indicated that β-sitosterol was predominant in the oils, except AO; spinasterol was only present in AO. Polyphenol profiles underlined that OO was the richest in polyphenols; hydroxytyrosol was only found in OO; few polyphenols were detected in AO. The oils studied have antioxidant activities, and all of them, except NSO, prevented 7KC-induced cell death. The antioxidant characteristics of AO were positively correlated with procatechic acid and compestanol levels.
Conclusion
Based on their biochemical profiles, antioxidant and cytoprotective characteristics, AO, OO, and MTSO are potentially beneficial to human health.
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