The Effect of Whole-Grain Intake on Biomarkers of Subclinical Inflammation: A Comprehensive Meta-analysis of Randomized Controlled Trials
Rahmani S, Sadeghi O, Sadeghian M, Sadeghi N, Larijani B, Esmaillzadeh A
Advances in nutrition (Bethesda, Md.) · 25 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Tehran University of Medical Sciences and Health Services
- Gobierno
- National Institute for Medical Research Development
- Universidad u hospital
- Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences
- Universidad u hospital
- Students' Scientific Research Center
- Universidad u hospital
- Tehran University of Medical Sciences
Según 5 financiadores declarados.
Publicación
- Publicado
- 2019-06-05 · Adv Nutr · vol. 11 · número 1 · págs. 52–65
- Editorial
- Elsevier BV
- Citado
- 38 citas · más que el 65% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Adipokines, Inflammation, and Metabolic Diseases
- Palabras clave
- whole grain intake, subclinical inflammation, inflammatory markers, C-reactive protein, interleukin-6, TNF-α, plasminogen activator inhibitor-1, whole grain diet, isocaloric diet, dietary intervention, adults, effect size heterogeneity, publication bias, small study size bias, risk of bias
- MeSH
- humans, inflammation, c-reactive protein, plasminogen activator inhibitor 1, cytokines, diet, feeding behavior, adult, aged, aged, 80 and over, middle aged, female, male, randomized controlled trials as topic, biomarkers, whole grains
6 autores
- Sepideh Rahmani🇮🇷Isfahan University of Medical Sciences
- Omid Sadeghi🇮🇷Tehran University of Medical Sciences
- Mehdi Sadeghian🇮🇷Ahvaz Jundishapur University of Medical Sciences
- Narges Sadeghi🇮🇷Ahvaz Jundishapur University of Medical Sciences
- Bagher A. Larijani🇮🇷Endocrinology and Metabolism Clinical Sciences Institute; Tehran University of Medical Sciences
- Ahmad Esmaillzadeh🇮🇷 · autor de correspondenciaIsfahan University of Medical Sciences; Obesity and Eating Habits Research Center; Endocrinology and Metabolism Molecular-Cellular Sciences Institute; Tehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Findings on the effect of whole-grain consumption on inflammatory biomarkers are conflicting. This study aimed to summarize available studies on the effects of whole-grain consumption on inflammatory biomarkers in adults. Online databases including PubMed, Scopus, ISI Web of Science, and Google Scholar were searched for relevant studies published up to January 2018, using relevant keywords. We included randomized controlled trials (RCTs) investigating the effect of whole-grain foods or diets high in whole-grain foods on markers of inflammation. Studies were selected if they had a control diet low in whole grains or diets without whole grains, whether calorie restricted or not. We did not include studies that examined the effect of individual grain components, including bran or germ, or fiber-based diets. Overall, 14 RCTs, with 1238 individuals aged ≥18 y, were included. Pooling 13 effect sizes from 11 RCTs on serum C-reactive protein (CRP) concentrations, we found no significant effect of whole-grain consumption on serum CRP concentrations [weighted mean difference (WMD): -0.29 mg/L; 95% CI: -1.10, 0.52 mg/L]. However, the beneficial effects of whole-grain intake on serum CRP concentrations were observed in studies in individuals with elevated serum concentrations of CRP and studies with isocaloric diets. Combining 11 effect sizes from 10 RCTs, we found no significant effect of whole-grain consumption on serum IL-6 concentrations (WMD: -0.08 pg/mL; 95% CI: -0.27, 0.11 pg/mL). Nevertheless, we observed a significant effect of whole-grain consumption on serum IL-6 concentrations in studies in unhealthy individuals. A nonsignificant effect of whole-grain intake on circulating serum TNF-α concentrations was also seen when we summarized effect sizes from 7 RCTs (WMD: -0.06 pg/mL; 95% CI: -0.25, 0.14 pg/mL). Such a nonsignificant effect was observed for serum concentrations of plasminogen activator inhibitor-1 (PAI-1) (WMD: -3.59; 95% CI: -1.25, 8.44 kU/L). Unlike observational studies, we found no significant effect of whole-grain consumption on serum concentrations of inflammatory cytokines, including serum concentrations of CRP, IL-6, TNF-α, and PAI-1. However, beneficial effects of whole grains were found in some subgroups. Given the high between-study heterogeneity, deriving firm conclusions is difficult.
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