Markers of adipose tissue inflammation are transiently elevated during intermittent fasting in women who are overweight or obese
Liu B, Hutchison AT, Thompson CH, Lange K, Heilbronn LK
Obesity research & clinical practice · 41 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Health and Medical Research Council
Según 1 financiador declarado.
Publicación
- Publicado
- 2019-07-01 · Obes Res Clin Pract · vol. 13 · número 4 · págs. 408–415
- Editorial
- Elsevier BV
- Citado
- 52 citas · más que el 92% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Adipokines, Inflammation, and Metabolic Diseases · Adipose Tissue and Metabolism
- Palabras clave
- intermittent fasting, adipose tissue inflammation, skeletal muscle inflammation, macrophage polarization, M1 macrophages, M2 macrophages, free fatty acids, adipose tissue lipolysis, TNF-α, interleukin-6, IL-10, obese women, weight loss, extracellular matrix deposition
- MeSH
- muscle, skeletal, macrophages, humans, panniculitis, obesity, fatty acids, nonesterified, cytokines, caloric restriction, fasting, adult, aged, middle aged, female, subcutaneous fat, overweight, biomarkers
5 autores
- Bo Liu🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Amy T. Hutchison🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Campbell Henry Thompson🇦🇺The University of Adelaide
- Kylie M. Lange🇦🇺The University of Adelaide
- Leonie Kaye Heilbronn🇦🇺 · autor de correspondenciaSouth Australian Health and Medical Research Institute; The University of Adelaide
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
This study compared the effects of daily calorie restriction (DR) versus intermittent fasting (IF) on markers of inflammation and extracellular matrix deposition in adipose tissue and skeletal muscle in a controlled feeding trial in women with overweight or obesity.
Methods
Women (N = 76) were randomised to one of three diets and provided with all foods at 100% (IF100) or 70% (IF70 and DR70) of calculated energy requirements for 8 weeks. IF groups ate breakfast prior to fasting for 24-h on 3 non-consecutive days/week. Weight, body composition, serum non-esterified fatty acids (NEFA), tumour necrosis factor-alpha (TNFα), interleukin-6 (IL-6), interleukin-10 (IL-10), M1- and M2-macrophage markers by qPCR and immunohistochemistry in adipose tissue and skeletal muscle were measured following a 12-h overnight fast (fed day, all groups) and a 24-h fast (IF groups only).
Results
IF70 resulted in greater weight and fat losses and reductions in serum NEFA versus DR70 and IF100 (P +) in adipose tissue, and M2-macrophages (CD163+) in muscle were increased in IF70 and IF100 (all P < 0.05) and the changes in NEFA and mRNA of pan-macrophage marker CD68 in adipose tissue were positively correlated (r = 0.56, P = 0.002).
Conclusions
Unlike caloric restriction, IF transiently elevated markers of macrophage infiltration in adipose tissue and skeletal muscle, possibly in response to marked increases in adipose tissue lipolysis.
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