Predicting and Testing Bioavailability of Magnesium Supplements
Blancquaert L, Vervaet C, Derave W
Nutrients · 46 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2019-07-20 · Nutrients · vol. 11 · número 7 · pág. 1663
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 67 citas · más que el 89% de estudios similares · 2.6× el promedio de su campo
- Referencias
- 34 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Plant Micronutrient Interactions and Effects · Intestinal and Peritoneal Adhesions
- Palabras clave
- Bioavailability, In vivo, Magnesium, Pharmacology, Ingestion, Absorption (acoustics), Pharmacokinetics, Chemistry, Medicine, Biochemistry, Biotechnology, Biology, Materials science
- MeSH
- humans, magnesium, dosage forms, biological availability, dietary supplements, adolescent, adult, female, male, young adult, drug liberation
3 autores
- Laura Blancquaert🇧🇪Ghent University
- Chris Vervaet🇧🇪Ghent University
- Wim Derave🇧🇪Ghent University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Despite the presumption of the beneficial effects of magnesium supplementation, little is known about the pharmacokinetics of different magnesium formulations. We aimed to investigate the value of two in vitro approaches to predict bioavailability of magnesium and to validate this in subsequent in vivo testing. In vitro assessment of 15 commercially available magnesium formulations was performed by means of a Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) and by dissolution tests. Two magnesium formulations with contrasting bioavailability prediction from both in vitro tests (best vs. worst) were selected for in vivo testing in 30 subjects. In vivo bioavailability was compared following one acute ingestion by monitoring blood magnesium concentrations up to 6 h following intake. The in vitro tests showed a very wide variation in absorption and dissolution of the 15 magnesium products. In the in vivo testing, a significant different serum magnesium absorption profile was found up to 4 h following supplement ingestion for the two supplements with opposing in vitro test results. Moreover, maximal serum magnesium increase and total area under the curve were significantly different for both supplements (+6.2% vs. +4.6% and 6.87 vs. 0.31 mM.min, respectively). Collectively, poor bioaccessibility and bioavailability in the SHIME model clearly translated into poor dissolution and poor bioavailability in vivo. This provides a valid methodology for the prediction of in vivo bioavailability and effectiveness of micronutrients by specific in vitro approaches.
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