Assessment of the effect of sachet formulation of almond (Amygdalus dulcis L.) on diarrhea prominent irritable bowel syndrome (IBS-D) symptoms: A clinical trial
Darvishmoghadam S, Ansari M, Ahmadipour H, Azimipour M, Esmaeilzade M, Zahedi MJ, Hayat Bakhsh Abbasi M, Ahmadi B, Asadi A, Sharififar F
Complementary therapies in medicine · 7 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Kerman University of Medical Sciences
- Universidad u hospital
- Vice Research Chancellor of Kerman University of Medical Sciences
- Universidad u hospital
- Gastroenterology and Hepatology Research Center
- Subvenciones
- Kerman University of Medical Sciences (1396/1195)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2019-07-04 · Complement Ther Med · vol. 45 · págs. 242–247
- Editorial
- Elsevier BV
- Citado
- 12 citas · más que el 81% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 25 trabajos
- Acceso
- De pago
- Áreas de investigación
- Gastrointestinal motility and disorders · Gut microbiota and health · Food composition and properties
- Palabras clave
- almond, diarrhea-predominant irritable bowel syndrome, low FODMAP diet, fructooligosaccharides, fermentable carbohydrates, defecation, abdominal pain, bloating, dietary intervention
- MeSH
- humans, irritable bowel syndrome, diarrhea, plant preparations, medicine, traditional, double-blind method, adult, iran, female, male, prunus dulcis
10 autores
- Sodaif Darvishmoghadam🇮🇷Kerman University of Medical Sciences
- Mehdi Ansari🇮🇷Kerman University of Medical Sciences
- Habibeh Ahmadipour🇮🇷Kerman University of Medical Sciences
- Mahnaz Azimipour🇮🇷Kerman University of Medical Sciences
- Maria Esmaeilzade🇮🇷Kerman University of Medical Sciences
- Mohammad Javad Zahedi🇮🇷Kerman University of Medical Sciences
- Mehdi Hayat Bakhsh Abbasi🇮🇷Kerman University of Medical Sciences
- Bijan Ahmadi🇮🇷Kerman University of Medical Sciences
- Amir Asadi🇮🇷Kerman University of Medical Sciences
- Fariba Sharififar🇮🇷 · autor de correspondenciaKerman University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Almond has been listed in the low FODMAPs (Fermentable Oligo-, Di-, Mono saccharides And Polyols) and is recommended for infant diarrhea and gastrointestinal problem in Iranian folk medicine. In this work, sachet of almond has been designed, formulated and is studied on the clinical symptoms of diarrhea prominent irritable bowel syndrome (IBS-D).
Design
almond was standardized on the basis of total protein and carbohydrate content. A sachet of almond and wheat flour (placebo) was formulated and their physicochemical characteristics were investigated.
Intervention
In a double blind randomized trial, fifty IBS-D patients were randomly enrolled into the almond and placebo groups, ranked in respect to the severity of symptoms to mild-moderate and severe disease. The patients received almond or placebo sachet (40 g/day,20 days) respectively.
Main outcome measure
Patients were assessed for bowel habit, pain severity and frequency and bloating and data was recorded in a data collecting form.
Results
The results showed that none of the primary outcomes of the disease is improved in the patients treated with almond. The bowel movement and severity of the pain was significantly increased in the almond treated patients compared to the placebo and baseline (p < 0.05).
Conclusion
Almond contains high content of oligo-fructan which in high intake might result in a large amount of fermentable carbohydrates that can exacerbate the symptoms of the disease. So, despite the almond inclusion in the low-FODMAPs, the amount of almond intake is a determining factor and here we have controversial results for almond intake in patients with IBS. Mental health and physical activity of patients are also involved in the disease.
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