A Mediterranean Diet Rich in Extra-Virgin Olive Oil Is Associated with a Reduced Prevalence of Nonalcoholic Fatty Liver Disease in Older Individuals at High Cardiovascular Risk
Pintó X, Fanlo-Maresma M, Corbella E, Corbella X, Mitjavila MT, Moreno JJ, Casas R, Estruch R, Corella D, Bulló M, Ruiz-Canela M, Castañer O, Martinez JA, Ros E, PREDIMED Study Investigators
The Journal of nutrition · 77 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
- Gobierno
- Instituto de Salud Carlos III
- Gobierno
- CIBER de Fisiopatología de la Obesidad y Nutrición
- Subvenciones
- Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición (CB12/03/); Instituto de Salud Carlos III (PI13/01123); Instituto de Salud Carlos III (CB06/03/0028); Instituto de Salud Carlos III (RD06/0045); Instituto de Salud Carlos III (JR14/00008); Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición (CB06/03); Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición (CB06/03/0028); Instituto de Salud Carlos III (CB06/03); Instituto de Salud Carlos III (RD06/0045/0007); Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición (PI13/01123); Instituto de Salud Carlos III (CB12/03/30012)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2019-06-06 · J Nutr · vol. 149 · número 11 · págs. 1920–1929
- Editorial
- Elsevier BV
- Citado
- 101 citas · más que el 99% de estudios similares · 10.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 46 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Liver Disease Diagnosis and Treatment · Alcohol Consumption and Health Effects
- Palabras clave
- Mediterranean diet, extra virgin olive oil, non-alcoholic fatty liver disease, hepatic steatosis, liver fat, mixed nuts, cardiovascular risk, type 2 diabetes, omega-3 fatty acids, PREDIMED trial, dietary intervention, older adults, adiposity, glycemic control
- MeSH
- liver, humans, nuts, cardiovascular diseases, magnetic resonance imaging, diet, fat-restricted, prevalence, risk factors, primary prevention, diet, mediterranean, aged, middle aged, spain, female, male, non-alcoholic fatty liver disease, olive oil
14 autores
- Xavier Pintó🇪🇸 · autor de correspondenciaInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Bellvitge University Hospital; Institut d'Investigació Biomédica de Bellvitge
- Marta Fanlo‐Maresma🇪🇸Bellvitge University Hospital; Institut d'Investigació Biomédica de Bellvitge
- Emili Corbella🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Bellvitge University Hospital; Institut d'Investigació Biomédica de Bellvitge
- Xavier Corbella🇪🇸Bellvitge University Hospital; Universitat Internacional de Catalunya; Institut d'Investigació Biomédica de Bellvitge
- Maria Teresa Mitjavila🇪🇸Universitat de Barcelona
- Juan Jose Moreno🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Universitat de Barcelona
- Rosa Mª Casas🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Ramón Estruch🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Dolores Corella🇪🇸Universitat de València; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
- Mònica Bulló🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Institut de Recerca Biomèdica Catalunya Sud; Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili
- Miguel Ruiz‐Canela🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Universidad de Navarra
- Olga Castañer🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital del Mar Research Institute
- J. Alfredo Martinez🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Bellvitge University Hospital; Institut d'Investigació Biomédica de Bellvitge; IMDEA Food; Universidad de Navarra
- Emilio Ros🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Adherence to a Mediterranean diet (MedDiet) is thought to reduce liver steatosis.
Objectives
To explore the associations with liver steatosis of 3 different diets: a MedDiet + extra-virgin olive oil (EVOO), MedDiet + nuts, or a control diet.
Methods
This was a subgroup analysis nested within a multicenter, randomized, parallel-group clinical trial, PREvención con DIeta MEDiterránea (PREDIMED trial: ISRCTN35739639), aimed at assessing the effect of a MedDiet on the primary prevention of cardiovascular disease. One hundred men and women (mean age: 64 ± 6 y), at high cardiovascular risk (62% with type 2 diabetes) from the Bellvitge-PREDIMED center were randomly assigned to a MedDiet supplemented with EVOO, a MedDiet supplemented with mixed nuts, or a control diet (advice to reduce all dietary fat). No recommendations to lose weight or increase physical activity were given. Main measurements were the percentage of liver fat and the diagnosis of steatosis, which were determined by NMR imaging. The association of diet with liver fat content was analyzed by bivariate analysis after a median follow-up of 3 y.
Results
Baseline adiposity and cardiometabolic risk factors were similar among the 3 treatment arms. At 3 y after the intervention hepatic steatosis was present in 3 (8.8%), 12 (33.3%), and 10 (33.3%) of the participants in the MedDiet + EVOO, MedDiet + nuts, and control diet groups, respectively (P = 0.027). Respective mean values of liver fat content were 1.2%, 2.7%, and 4.1% (P = 0.07). A tendency toward significance was observed for the MedDiet + EVOO group compared with the control group. Median values of urinary 12(S)-hydroxyeicosatetraenoic acid/creatinine concentrations were significantly (P = 0.001) lower in the MedDiet + EVOO (2.3 ng/mg) than in the MedDiet + nuts (5.0 ng/mg) and control (3.9 ng/mg) groups. No differences in adiposity or glycemic control changes were seen between groups.
Conclusions
An energy-unrestricted MedDiet supplemented with EVOO, a food with potent antioxidant and anti-inflammatory properties, is associated with a reduced prevalence of hepatic steatosis in older individuals at high cardiovascular risk.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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