Starch and β-glucan in a whole-grain-like structural form improve hepatic insulin sensitivity in diet-induced obese mice
Luo K, Wang X, Zhang G
Food & function · 14 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (31471585)
Según 1 financiador declarado.
Publicación
- Publicado
- 2019-01-01 · Food Funct · vol. 10 · número 8 · págs. 5091–5101
- Editorial
- Royal Society of Chemistry
- Citado
- 19 citas · más que el 69% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 49 trabajos
- Acceso
- De pago
- Áreas de investigación
- Metabolism, Diabetes, and Cancer · Pancreatic function and diabetes · Natural Antidiabetic Agents Studies
- Palabras clave
- Insulin resistance, Endocrinology, Insulin sensitivity, Internal medicine, Insulin, Glucan, Starch, Homeostasis, Resistant starch, Glucose homeostasis, Chemistry, Medicine, Biochemistry
- MeSH
- liver, animals, mice, inbred c57bl, humans, mice, mice, obese, insulin resistance, obesity, starch, insulin, glucose-6-phosphatase, phosphoenolpyruvate carboxykinase (atp), beta-glucans, interleukin-6, male, proto-oncogene proteins c-akt, diet, high-fat
3 autores
- Kaiyun Luo🇨🇳🇬🇧Jiangnan University; Institute of Food Science and Technology; Institute of Food Science & Technology; State Key Laboratory of Food Science and Technology
- Xufeng Wang🇨🇿🇨🇳Czech Academy of Sciences, Institute of Biotechnology; Fuzhou University
- Genyi Zhang🇨🇳🇬🇧 · autor de correspondenciaJiangnan University; Institute of Food Science and Technology; Institute of Food Science & Technology; State Key Laboratory of Food Science and Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Whole-grain food (WGF) is well known for its anti-diabetic effect, and alleviation of obesity-induced insulin resistance (IR) might be one of the underlying mechanisms. In the current study, the effects of starch, as the main component in WGF, and β-glucan in a whole-grain-like structural form (WGLSF) on hepatic IR and glucose homeostasis were investigated using high-fat (HF)-induced obese C57BL/6J mice. After treatment for 8 weeks, the body weight gain and IR of the mice were significantly reduced. The hepatic Akt, the key component in insulin signaling, was activated, and the hepatic expression and protein levels of glucose-6-phosphatase (G-6-P) and phosphoenolpyruvate carboxykinase (PEPCK) were reduced. Moreover, WGLSF effectively reduced the hepatic levels of free fatty acids and the pro-inflammatory cytokines TNF-α, IL-6, and NF-κB. Additionally, the reduced level of the phosphorylated c-Jun-N-terminal kinases (JNK) indicated that WGLSF treatment might inactivate the JNK signaling, leading to improved hepatic IR. These results demonstrated that starch and β-glucan in a whole grain-like structural form have the potential as a dietary strategy to combat obesity-induced hepatic IR for improved health.
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