Efficacy of omega-3 PUFAs in depression: A meta-analysis
Liao Y, Xie B, Zhang H, He Q, Guo L, Subramanieapillai M, Fan B, Lu C, McIntyre RS
Translational psychiatry · 299 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (81761128030)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-08-05 · Transl Psychiatry · vol. 9 · número 1 · pág. 190
- Editorial
- Springer Nature
- Citado
- 420 citas · más que el 98% de estudios similares · 7.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Delphi Technique in Research · Eicosanoids and Hypertension Pharmacology
- Palabras clave
- Meta-analysis, Eicosapentaenoic acid, Funnel plot, Docosahexaenoic acid, Polyunsaturated fatty acid, Placebo, Publication bias, Randomized controlled trial, Internal medicine, Medicine, Depression (economics), Gastroenterology, Fatty acid, Chemistry, Biochemistry, Pathology
- MeSH
- humans, fatty acids, omega-3, treatment outcome, double-blind method, depressive disorder, randomized controlled trials as topic
9 autores
- Yuhua Liao🇨🇳Shenzhen Nanshan Center for Chronic Disease Control
- Bo Xie🇨🇳Shenzhen Nanshan Center for Chronic Disease Control
- Huimin Zhang🇨🇳Shenzhen Nanshan Center for Chronic Disease Control
- Qian He🇨🇳Shenzhen Nanshan Center for Chronic Disease Control
- Lan Guo🇨🇳Sun Yat-sen University
- Mehala Subramanieapillai🇨🇦University Health Network; University of Toronto
- Beifang Fan🇨🇳 · autor de correspondenciaShenzhen Nanshan Center for Chronic Disease Control
- Ciyong Lu🇨🇳 · autor de correspondenciaSun Yat-sen University
- Roger S. McIntyre🇨🇦University Health Network; University of Toronto
Resumen
El texto original del estudio, en el idioma en que se publicó.
We conducted this meta-analysis of double-blind randomized placebo-controlled trials to estimate the efficacy of omega-3 polyunsaturated fatty acids (PUFAs), especially docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), in the improvement of depression. We applied a systematic bibliographic search in PubMed and EMBASE for articles published prior to 20 December 2017. This meta-analysis was performed using RevMan 5.3 and R 3.4.3, and means and standard deviations were calculated in fixed- or random-effects models based on the results of the Q-test. A sensitivity analysis was also conducted to evaluate the stability of the results, and publication bias was evaluated by a funnel plot and Egger's linear regression analysis. Our search resulted in 180 articles; we analyzed 26 studies, which included 2160 participants. The meta-analysis showed an overall beneficial effect of omega-3 polyunsaturated fatty acids on depression symptoms (SMD = -0.28, P = 0.004). Compared with placebo, EPA-pure (=100% EPA) and EPA-major formulations (≥60% EPA) demonstrated clinical benefits with an EPA dosage ≤1 g/d (SMD = -0.50, P = 0.003, and SMD = -1.03, P = 0.03, respectively), whereas DHA-pure and DHA-major formulations did not exhibit such benefits.Current evidence supports the finding that omega-3 PUFAs with EPA ≥ 60% at a dosage of ≤1 g/d would have beneficial effects on depression. Further studies are warranted to examine supplementation with omega-3 PUFAs for specific subgroups of subjects with inflammation, severity of depression, and the dose response for both EPA and DHA supplementation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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