Relationship between 25-Hydroxyvitamin D, bone density, and Parkinson's disease symptoms
Zhang HJ, Zhang JR, Mao CJ, Li K, Wang F, Chen J, Liu CF
Acta neurologica Scandinavica · 29 citas
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Government of Jiangsu Province
- Gobierno
- National Key Research and Development Program of China
- Universidad u hospital
- Suzhou Clinical Research Center of Neurological Disease
- Gobierno
- Social development projects in Jiangsu Province
- Gobierno
- National Key R&D Program of China
- Gobierno
- Jiangsu Provincial Medical Key Discipline Project
- Subvenciones
- Government of Jiangsu Province (BE2018658); National Key Research and Development Program of China (2017YFC 0909100); Government of Jiangsu Province (BE2017653); Government of Jiangsu Province (ZDXKB2016022)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2019-08-06 · Acta Neurol Scand · vol. 140 · número 4 · págs. 274–280
- Editorial
- Wiley
- Citado
- 39 citas · más que el 89% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 48 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Parathyroid Disorders and Treatments
- Palabras clave
- Medicine, Internal medicine, Vitamin D and neurology, Femoral neck, Bone mineral, Depression (economics), Pittsburgh Sleep Quality Index, Endocrinology, vitamin D deficiency, Anxiety, Parkinson's disease, Bone density, Gastroenterology, Osteoporosis, Disease, Insomnia, Sleep quality, Psychiatry
- MeSH
- femur neck, lumbar vertebrae, humans, parkinson disease, vitamin d deficiency, vitamin d, absorptiometry, photon, accidental falls, bone density, aged, middle aged, female, male
7 autores
- Huijun Zhang🇨🇳Soochow University; Second Affiliated Hospital of Soochow University
- Jin‐Ru Zhang🇨🇳Soochow University; Second Affiliated Hospital of Soochow University
- Chengjie Mao🇨🇳Soochow University; Second Affiliated Hospital of Soochow University
- Kai Li🇨🇳Soochow University; Second Affiliated Hospital of Soochow University
- Fen Wang🇨🇳Soochow University
- Jing Chen🇨🇳 · autor de correspondenciaSoochow University; Second Affiliated Hospital of Soochow University
- Chun‐Feng Liu🇨🇳 · autor de correspondenciaSoochow University; Second Affiliated Hospital of Soochow University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Vitamin D deficiency is widespread in patients with Parkinson's disease (PD). Our aim was to determine whether serum vitamin D levels correlated with bone mineral density (BMD) and non-motor symptoms in patients with PD.
Materials & methods
A consecutive series of 182 patients with PD and 185 healthy controls were included. Serum 25-hydroxyvitamin D (25[OH]D) levels were measured by immunoassay, while BMD of the lumbar spine and femoral neck was measured by dual-energy X-ray absorptiometry. Associations between serum vitamin D levels and clinical data were evaluated using partial correlation analysis.
Results
Patients with PD had significantly lower serum 25(OH)D levels relative to healthy controls (49.75 ± 14.11 vs 43.40 ± 16.51, P < 0.001). Furthermore, PD patients with lower vitamin D levels had a significantly higher frequency of falls (P = 0.033) and insomnia (P = 0.015). They also had significantly higher scores for the Pittsburgh Sleep Quality Index (PSQI; P = 0.014), depression (P = 0.020), and anxiety (P = 0.009). Finally, patients with PD also had a significantly lower mean BMD of the lumbar spine (P = 0.011) and femoral neck (P < 0.001). After adjusting for age, sex, and body mass index, vitamin D levels significantly correlated with falls, insomnia, and scores for the PSQI, depression, and anxiety.
Conclusions
In patients with PD, vitamin D levels significantly correlated with falls and some non-motor symptoms. However, no associations were found between BMD and the serum 25(OH)D levels in patients with PD. Thus, vitamin D supplementation is a potential therapeutic for non-motor PD symptoms.
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