Association between vitamin D supplementation and mortality: systematic review and meta-analysis
Zhang Y, Fang F, Tang J, Jia L, Feng Y, Xu P, Faramand A
BMJ (Clinical research ed.) · 251 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Pittsburgh
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- West China Hospital, Sichuan University
- Subvenciones
- National Natural Science Foundation of China (81472361); National Natural Science Foundation of China (81100925)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-08-12 · BMJ · vol. 366 · pág. l4673
- Citado
- 369 citas · más que el 99% de estudios similares · 8.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 94 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Vitamin D Research Studies · Vitamin C and Antioxidants Research · Vitamin K Research Studies
- Palabras clave
- Medicine, Meta-analysis, Placebo, Internal medicine, Confidence interval, Vitamin, Relative risk, Randomized controlled trial, Vitamin D and neurology, Subgroup analysis, Cause of death, Disease, Pathology
- MeSH
- humans, neoplasms, cholecalciferol, ergocalciferols, vitamin d, mortality, dietary supplements, randomized controlled trials as topic
7 autores
- Yu Zhang🇨🇳Chengdu University
- Fang Fang🇨🇳 · autor de correspondenciaSichuan University; West China Hospital of Sichuan University
- Jingjing Tang🇨🇳Chinese University of Hong Kong, Shenzhen
- Lu Jia
- Yuning Feng🇨🇳Chengdu University
- Ping Xu🇨🇳Sichuan University; Sichuan Provincial Library
- Andrew M. Faramand🇺🇸University of Pittsburgh Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To investigate whether vitamin D supplementation is associated with lower mortality in adults.
Design
Systematic review and meta-analysis of randomised controlled trials.
Data sources
Medline, Embase, and the Cochrane Central Register from their inception to 26 December 2018.
Eligibility criteria for selecting studies
Randomised controlled trials comparing vitamin D supplementation with a placebo or no treatment for mortality were included. Independent data extraction was conducted and study quality assessed. A meta-analysis was carried out by using fixed effects and random effects models to calculate risk ratio of death in the group receiving vitamin D supplementation and the control group.
Main outcome measures
All cause mortality.
Results
52 trials with a total of 75 454 participants were identified. Vitamin D supplementation was not associated with all cause mortality (risk ratio 0.98, 95% confidence interval 0.95 to 1.02, I2=0%), cardiovascular mortality (0.98, 0.88 to 1.08, 0%), or non-cancer, non-cardiovascular mortality (1.05, 0.93 to 1.18, 0%). Vitamin D supplementation statistically significantly reduced the risk of cancer death (0.84, 0.74 to 0.95, 0%). In subgroup analyses, all cause mortality was significantly lower in trials with vitamin D3 supplementation than in trials with vitamin D2 supplementation (P for interaction=0.04); neither vitamin D3 nor vitamin D2 was associated with a statistically significant reduction in all cause mortality.
Conclusions
Vitamin D supplementation alone was not associated with all cause mortality in adults compared with placebo or no treatment. Vitamin D supplementation reduced the risk of cancer death by 16%. Additional large clinical studies are needed to determine whether vitamin D3 supplementation is associated with lower all cause mortality.
Study registration
PROSPERO registration number CRD42018117823.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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