Physical activity, dietary calcium to magnesium intake and mortality in the National Health and Examination Survey 1999-2006 cohort
Hibler EA, Zhu X, Shrubsole MJ, Hou L, Dai Q
International journal of cancer · 25 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Health and Human Services
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK-058404); National Cancer Institute (R01 CA202936); National Institutes of Health (R01 CA202936)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2019-08-21 · Int J Cancer · vol. 146 · número 11 · págs. 2979–2986
- Editorial
- Wiley
- Citado
- 36 citas · más que el 82% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutrition and Health in Aging · Magnesium in Health and Disease · Obesity, Physical Activity, Diet
- Palabras clave
- National Health and Nutrition Examination Survey, Cohort, Medicine, Environmental health, Calcium, Cohort study, Magnesium, Gerontology, Internal medicine, Chemistry, Population
- MeSH
- humans, neoplasms, cardiovascular diseases, chronic disease, calcium, dietary, magnesium, vitamin d, exercise, diet, nutrition surveys, nutritional status, dietary supplements, adult, middle aged, female, male
5 autores
- Elizabeth A. Hibler🇺🇸 · autor de correspondenciaNorthwestern University; Vanderbilt University
- Xiangzhu Zhu🇺🇸Vanderbilt University
- Martha J. Shrubsole🇺🇸Vanderbilt University
- Lifang Hou🇺🇸Northwestern University
- Qi Dai🇺🇸Vanderbilt University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Calcium and magnesium affect muscle mass and function. Magnesium and calcium are also important for optimal vitamin D status. Vitamin D status modifies the associations between physical activity and risk of incident cardiovascular disease (CVD) and CVD mortality. However, no study examined whether levels of magnesium and calcium and the ratio of dietary calcium to magnesium (Ca:Mg) intake modify the relationship between physical activity and mortality. We included 20,295 National Health and Nutrition Examination Survey participants (1999-2006) aged >20 years with complete dietary, physical activity and mortality data (2,663 deaths). We assessed physical activity based on public health guidelines and sex-specific tertiles of MET-minutes/week. We used Cox proportional hazards models adjusted for potential confounding factors and stratified by the intakes of magnesium, calcium, Ca:Mg ratio. We found higher physical activity was significantly associated with reduced risk of total mortality and cause-specific mortality, regardless of Ca:Mg ratio, magnesium or calcium intake. In contrast, both moderate and high physical activity were significantly associated with substantially reduced risks of mortality due to cancer when magnesium intake was above the RDA level. We also found higher physical activity was significantly associated with a reduced risk of mortality due to cancer only when Ca:Mg ratios were between 1.7 and 2.6, although the interaction was not significant. Overall, dietary magnesium and, potentially, the Ca:Mg ratio modify the relationship between physical activity and cause-specific mortality. Further study is important to understand the modifying effects of the balance between calcium and magnesium intake on physical activity for chronic disease prevention.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.