Acute Respiratory Tract Infection and 25-Hydroxyvitamin D Concentration: A Systematic Review and Meta-Analysis
Pham H, Rahman A, Majidi A, Waterhouse M, Neale RE
International journal of environmental research and public health · 95 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Queensland
- Gobierno
- National Health and Medical Research Council
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-08-21 · Int J Environ Res Public Health · vol. 16 · número 17 · pág. 3020
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 141 citas · más que el 96% de estudios similares · 4.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 56 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Asthma and respiratory diseases · Chronic Obstructive Pulmonary Disease (COPD) Research
- Palabras clave
- Meta-analysis, Confidence interval, Odds ratio, Vitamin D and neurology, Medicine, Internal medicine, Respiratory tract infections, Observational study, Gastroenterology, vitamin D deficiency, Respiratory system
- MeSH
- humans, respiratory tract infections, acute disease, vitamins, vitamin d, observational studies as topic
5 autores
- Hai D. Pham🇦🇺 · autor de correspondenciaThe University of Queensland; QIMR Berghofer Medical Research Institute
- Aninda Rahman🇦🇺The University of Queensland; QIMR Berghofer Medical Research Institute
- Azam Majidi🇦🇺The University of Queensland; QIMR Berghofer Medical Research Institute
- Mary A. Waterhouse🇦🇺QIMR Berghofer Medical Research Institute
- Rachel E. Neale🇦🇺The University of Queensland; QIMR Berghofer Medical Research Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Observational studies and randomised controlled studies suggest that vitamin D plays a role in the prevention of acute respiratory tract infection (ARTI); however, findings are inconsistent and the optimal serum 25-hydroxyvitamin D (25(OH)D) concentration remains unclear. To review the link between 25(OH)D concentration and ARTI, we searched PubMed and EMBASE databases to identify observational studies reporting the association between 25(OH)D concentration and risk or severity of ARTI. We used random-effects meta-analysis to pool findings across studies. Twenty-four studies were included in the review, 14 were included in the meta-analysis of ARTI risk and five in the meta-analysis of severity. Serum 25(OH)D concentration was inversely associated with risk and severity of ARTI; pooled odds ratios (95% confidence interval) were 1.83 (1.42-2.37) and 2.46 (1.65-3.66), respectively, comparing the lowest with the highest 25(OH)D category. For each 10 nmol/L decrease in 25(OH)D concentration, the odds of ARTI increased by 1.02 (0.97-1.07). This was a non-linear trend, with the sharpest increase in risk of ARTI occurring at 25(OH)D concentration < 37.5 nmol/L. In conclusion, there is an inverse non-linear association between 25(OH)D concentration and ARTI.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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