The Effect of Magnesium Intake on Stroke Incidence: A Systematic Review and Meta-Analysis With Trial Sequential Analysis
Zhao B, Hu L, Dong Y, Xu J, Wei Y, Yu D, Xu J, Zhang W
Frontiers in neurology · 23 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- Chinese Academy of Medical Sciences
- Universidad u hospital
- Peking Union Medical College Hospital
- Universidad u hospital
- Peking Union Medical College
- Subvenciones
- National Natural Science Foundation of China (81560345)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2019-08-07 · Front Neurol · vol. 10 · pág. 852
- Editorial
- Frontiers Media
- Citado
- 35 citas · más que el 62% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 30 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Cardiovascular Health and Disease Prevention · Sodium Intake and Health
- Palabras clave
- Medicine, Stroke (engine), Relative risk, Meta-analysis, Cochrane Library, Internal medicine, Incidence (geometry), Magnesium, Prospective cohort study, Intracerebral hemorrhage, Cohort study, Subarachnoid hemorrhage, Surgery, Confidence interval
8 autores
- Binghao Zhao🇨🇳Nanchang University; Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital; First Affiliated Hospital of Nanchang University
- Lei Hu🇨🇳Nanchang University; Second Affiliated Hospital of Nanchang University
- Yifei Dong🇨🇳Nanchang University; Second Affiliated Hospital of Nanchang University
- Jingsong Xu🇨🇳Nanchang University; Second Affiliated Hospital of Nanchang University; First Affiliated Hospital of Nanchang University
- Yiping Wei🇨🇳Nanchang University; First Affiliated Hospital of Nanchang University
- Dongliang Yu🇨🇳Nanchang University; First Affiliated Hospital of Nanchang University
- Jianjun Xu🇨🇳Nanchang University; Second Affiliated Hospital of Nanchang University; First Affiliated Hospital of Nanchang University
- Wenxiong Zhang🇨🇳 · autor de correspondenciaNanchang University; First Affiliated Hospital of Nanchang University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: The effect of magnesium on stroke has been consistently discussed less, and the results of previous studies have been contradictory. We reviewed the latest literature and quantified robust evidence of the association between magnesium intake and stroke risk. Methods: PubMed, EMBASE, the Cochrane Library, the Web of Science and ClinicalTrials.gov were searched through inception to January 15, 2019 for prospective cohort studies on magnesium intake and the incidence of stroke. Results: Fifteen studies with low bias involving 18 cohorts were entered into this study. The summary relative risk (RR) was significantly reduced by 11% for total stroke (RR: 0.89 [95% CI, 0.83-0.94]; P P = 0.001), comparing the highest magnesium intake category to the lowest. After adjusting for calcium intake, the inverse association still existed for total stroke (RR: 0.89 ([95% CI, 0.80-0.99]; P = 0.040). There was an inverse but non-significant association for hemorrhagic stroke, subarachnoid hemorrhage and intracerebral hemorrhage. The quantitative associations for total and ischemic stroke were robust. Importantly, high-risk females who had a body mass index (BMI) ≥25 kg/m2 and who were subjected to a ≥12 y follow-up exhibited a greater decrease in RRs as a result of magnesium intake. For each 100 mg/day increase in magnesium, the risk for total stroke was reduced by 2% and the risk for ischemic stroke was reduced by 2%. Conclusions: Increasing magnesium intake may be a crucial component of stroke prevention that acts in a dose-dependent manner. However, the conclusion is limited by the observational nature of the studies examined, and further randomized controlled trials are still needed.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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