Financiado en parte por Lantmännens Forskningsstiftelse, Lantmännen Research Foundation
Prevotella Abundance Predicts Weight Loss Success in Healthy, Overweight Adults Consuming a Whole-Grain Diet Ad Libitum: A Post Hoc Analysis of a 6-Wk Randomized Controlled Trial
Christensen L, Vuholm S, Roager HM, Nielsen DS, Krych L, Kristensen M, Astrup A, Hjorth MF
The Journal of nutrition · 129 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Lantmännens Forskningsstiftelse
- Grupo de la industria
- Lantmännen Research Foundation
Según 2 financiadores declarados.
Publicación
- Publicado
- 2019-07-26 · J Nutr · vol. 149 · número 12 · págs. 2174–2181
- Editorial
- Elsevier BV
- Citado
- 160 citas · más que el 96% de estudios similares · 4.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Gut microbiota and health · Nutritional Studies and Diet · Oral microbiology and periodontitis research
- Palabras clave
- Prevotella, gut microbiota, weight loss, whole grain diet, overweight adults, dietary fiber, appetite, satiety, gut-brain axis, intestinal permeability, gut dysbiosis
- MeSH
- feces, humans, prevotella, weight loss, adult, aged, middle aged, female, male, overweight, whole grains
8 autores
- Lars H. Christensen🇩🇰 · autor de correspondenciaUniversity of Copenhagen
- Stine Vuholm🇩🇰University of Copenhagen
- Henrik Munch Roager🇩🇰University of Copenhagen
- Dennis Sandris Nielsen🇩🇰University of Copenhagen
- Łukasz Krych🇩🇰University of Copenhagen
- Mette Kristensen🇩🇰University of Copenhagen
- Arne Vernon Astrup🇩🇰University of Copenhagen
- Mads F. Hjorth🇩🇰University of Copenhagen
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The key to effective weight loss may be to match diet and gut microbes, since recent studies have found that subjects with high Prevotella abundances in their gut microbiota lose more weight on diets rich in fiber than subjects with low Prevotella abundances.
Objectives
We reanalyzed a 6-wk, parallel, randomized trial to investigate difference in body weight changes when participants, stratified by fecal microbiota composition, consumed ad libitum a whole-grain (WG) or a refined-wheat (RW) diet.
Methods
We stratified 46 (19 men, 27 women; ages 30-65 y) healthy, overweight adults by baseline Prevotella-to-Bacteroides ratios and Prevotella abundances. Subjects with no Prevotella were analyzed separately (n = 24). Compared with the RW diet (mean = 221 g/d), the WG diet (mean = 228 g/d) had a higher fiber content (33 g/d compared with 23 g/d). Linear mixed models and correlations were applied to link 6-wk changes in body weights and metabolic and microbiota markers, according to Prevotella groups and diets.
Results
The Prevotella abundances correlated inversely with weight changes (r = -0.34; P = 0.043). Consequently, subjects with high Prevotella abundances (n = 15) spontaneously lost 1.80 kg (95% CI: -3.23, -0.37 kg; P = 0.013) more on the WG diet than on the RW diet, whereas those with low Prevotella abundances (n = 31) were weight stable (-0.22 kg; 95% CI: -1.40, 0.96 kg; P = 0.72). Thus, the mean difference between the Prevotella groups was 2.02 kg (95% CI: -3.87, -0.17 kg; P = 0.032). Subjects with no Prevotella lost 1.59 kg (95% CI: -2.65, -0.52 kg; P = 0.004) more on the WG diet than on the RW diet. No 6-wk changes in appetite sensations, glucose metabolisms, or fecal SCFAs were associated with the Prevotella groups.
Conclusions
Healthy, overweight adults with high Prevotella abundances lost more weight than subjects with low Prevotella abundances when consuming a diet rich in WG and fiber ad libitum for 6 wk. This further supports enterotypes as a potential biomarker in personalized nutrition for obesity management. This t rial was registered at clinicaltrials.gov as NCT02358122.
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