Financiado en parte por Top Sector Agri and Food, GoodMills Innovation GmbH, Dutch Bakery Center
Whole Grain Wheat Consumption Affects Postprandial Inflammatory Response in a Randomized Controlled Trial in Overweight and Obese Adults with Mild Hypercholesterolemia in the Graandioos Study
Hoevenaars FPM, Esser D, Schutte S, Priebe MG, Vonk RJ, van den Brink WJ, van der Kamp JW, Stroeve JHM, Afman LA, Wopereis S
The Journal of nutrition · 34 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Top Sector Agri and Food
- Universidad u hospital
- Universitair Medisch Centrum Groningen
- Universidad u hospital
- Wageningen University and Research
- Empresa
- GoodMills Innovation GmbH
- Universidad u hospital
- TNO roadmap Nutrition and Health
- Grupo de la industria
- Dutch Bakery Center
- Gobierno
- Topsector Agri & Food
- Subvenciones
- Top Sector Agri and Food (TKI-AF 12083)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-07-05 · J Nutr · vol. 149 · número 12 · págs. 2133–2144
- Editorial
- Elsevier BV
- Citado
- 58 citas · más que el 93% de estudios similares · 3.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Dietary Effects on Health · Food composition and properties · Nutritional Studies and Diet
- Palabras clave
- Postprandial, Medicine, Overweight, Internal medicine, Randomized controlled trial, Meal, Endocrinology, Obesity, Gastroenterology, Insulin
- MeSH
- humans, triticum, hypercholesterolemia, obesity, inflammation, double-blind method, postprandial period, adult, aged, middle aged, female, male, overweight
10 autores
- Femke P. M. Hoevenaars🇳🇱Netherlands Organisation for Applied Scientific Research
- Diederik Esser🇳🇱Wageningen University & Research
- Sophie Schutte🇳🇱Wageningen University & Research
- Marion G. Priebe🇳🇱University Medical Center Groningen; University of Groningen
- Roel J. Vonk🇳🇱University Medical Center Groningen; University of Groningen
- Willem J van den Brink🇳🇱Netherlands Organisation for Applied Scientific Research
- J.W. van der Kamp🇳🇱Netherlands Organisation for Applied Scientific Research
- Johanna H. M. Stroeve🇳🇱Netherlands Organisation for Applied Scientific Research
- Lydia A. Afman🇳🇱Wageningen University & Research
- Suzan Wopereis🇳🇱 · autor de correspondenciaNetherlands Organisation for Applied Scientific Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Whole grain wheat (WGW) consumption is associated with health benefits in observational studies. However, WGW randomized controlled trial (RCT) studies show mixed effects.
Objectives
The health impact of WGW consumption was investigated by quantification of the body's resilience, which was defined as the "ability to adapt to a standardized challenge."
Methods
A double-blind RCT was performed with overweight and obese (BMI: 25-35 kg/m2) men (n = 19) and postmenopausal women (n = 31) aged 45-70 y, with mildly elevated plasma total cholesterol (>5 mmol/L), who were randomly assigned to either 12-wk WGW (98 g/d) or refined wheat (RW). Before and after the intervention a standardized mixed-meal challenge was performed. Plasma samples were taken after overnight fasting and postprandially (30, 60, 120, and 240 min). Thirty-one biomarkers were quantified focusing on metabolism, liver, cardiovascular health, and inflammation. Linear mixed-models evaluated fasting compared with postprandial intervention effects. Health space models were used to evaluate intervention effects as composite markers representing resilience of inflammation, liver, and metabolism.
Results
Postprandial biomarker changes related to liver showed decreased alanine aminotransferase by WGW (P = 0.03) and increased β-hydroxybutyrate (P = 0.001) response in RW. Postprandial changes related to inflammation showed increased C-reactive protein (P = 0.001), IL-6 (P = 0.02), IL-8 (P = 0.007), and decreased IL-1B (P = 0.0002) in RW and decreased C-reactive protein (P < 0.0001), serum amyloid A (P < 0.0001), IL-8 (P = 0.02), and IL-10 (P < 0.0001) in WGW. Health space visualization demonstrated diminished inflammatory (P < 0.01) and liver resilience (P < 0.01) by RW, whereas liver resilience was rejuvenated by WGW (P < 0.05).
Conclusions
Twelve-week 98 g/d WGW consumption can promote liver and inflammatory resilience in overweight and obese subjects with mildly elevated plasma cholesterol. The health space approach appeared appropriate to evaluate intervention effects as composite markers. This trial was registered at www.clinicaltrials.gov as NCT02385149.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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