Vitamin D supplementation and incident preeclampsia: A systematic review and meta-analysis of randomized clinical trials
Fogacci S, Fogacci F, Banach M, Michos ED, Hernandez AV, Lip GYH, Blaha MJ, Toth PP, Borghi C, Cicero AFG, Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group
Clinical nutrition (Edinburgh, Scotland) · 119 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Gobierno
- National Institute for Health Research (NIHR)
- Subvenciones
- National Institute for Health and Care Research (NF-SI-0616-10010); National Institute for Health and Care Research (NIHR201320)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2019-09-04 · Clin Nutr · vol. 39 · número 6 · págs. 1742–1752
- Editorial
- Elsevier BV
- Citado
- 182 citas · más que el 97% de estudios similares · 4.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 65 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Pregnancy and preeclampsia studies · Vitamin D Research Studies · Neurological Complications and Syndromes
- Palabras clave
- vitamin D supplementation, preeclampsia, preeclampsia prevention, pregnancy, vitamin D deficiency, timing of supplementation, dose-response relationship, calcium supplementation, maternal age
- MeSH
- humans, pre-eclampsia, avitaminosis, vitamin d, treatment outcome, incidence, risk assessment, risk factors, pregnancy, dietary supplements, adolescent, adult, middle aged, female, randomized controlled trials as topic, young adult, protective factors
10 autores
- Silvia Fogacci🇮🇹University of Bologna
- Federica Fogacci🇮🇹University of Bologna
- Maciej Banach🇵🇱 · autor de correspondenciaMedical University of Lodz; Polish Mother’s Memorial Hospital Research Institute; University of Zielona Góra
- Erin D. Michos🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Adrián Vladimir Hernández🇺🇸🇵🇪University of Connecticut; Universidad San Ignacio de Loyola
- Gregory Y.H. Lip🇬🇧University of Liverpool; Liverpool Heart and Chest Hospital
- Michael Joseph Blaha🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Peter Paul Toth🇺🇸Johns Hopkins University; Johns Hopkins Medicine; CGH Medical Center
- Claudio Borghi🇮🇹University of Bologna
- Arrigo F.G. Cicero🇮🇹 · autor de correspondenciaUniversity of Bologna
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Maternal vitamin D deficiency has been associated with an increased risk for preeclampsia. Despite this, the current evidence regarding the efficacy of vitamin D supplementation in preventing preeclampsia is controversial. To assess the impact of vitamin D supplementation on the risk of preeclampsia, we performed a systematic review of the literature and a meta-analysis of the available randomized clinical trials (RCTs).
Methods
The primary outcome was preeclampsia. Subgroup analyses were carried out considering the timing of the supplementation, type of intervention and the study design. Meta-regression analysis, including the amount of vitamin D and maternal age, were planned to explore heterogeneity (PROSPERO database registration number: CRD42019119207).
Results
Data were pooled from 27 RCTs comprising 59 arms, which included overall 4777 participants, of whom 2487 were in the vitamin D-treated arm and 2290 in the control arm. Vitamin D administration in pregnancy was associated with a reduced risk of preeclampsia (odd ratio [OR] 0.37, 95% confidence interval [CI]: 0.26, 0.52; I2 = 0%). If the vitamin D supplementation was started up to 20 weeks' gestation, the odds was a little lower (OR 0.35, 95% CI: 0.24, 0.50, p < 0.001). The effect was largely independent of the supplementation cessation (until delivery or not), type of intervention (vitamin D alone or in association with calcium), and study design. Increasing dose of vitamin D was associated with reduced incidence of preeclampsia (slope of log OR: -1.1, 95% CI: -1.73, -0.46; p < 0.001).
Conclusions
Results suggest that vitamin D supplementation may be useful in preventing preeclampsia. These data are especially useful for health-care providers who engage in the management of pregnant women at risk for preeclampsia. Our findings are a call for action to definitively address vitamin D supplementation as a possible intervention strategy in preventing preeclampsia in pregnancy.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.