Examining the effects of creatine supplementation in augmenting adaptations to resistance training in patients with prostate cancer undergoing androgen deprivation therapy: a randomised, double-blind, placebo-controlled trial
Fairman CM, Kendall KL, Newton RU, Hart NH, Taaffe DR, Chee R, Tang CI, Galvão DA
BMJ open · 15 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Cancer Council Western Australia
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-09-01 · BMJ Open · vol. 9 · número 9 · pág. e030080
- Editorial
- BMJ
- Citado
- 18 citas · más que el 69% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 64 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Muscle metabolism and nutrition · Nutrition and Health in Aging · Cancer survivorship and care
- Palabras clave
- creatine supplementation, resistance training, prostate cancer, androgen deprivation therapy, body composition, fat-free mass, muscle strength, physical function, quality of life, cancer patients
- MeSH
- humans, prostatic neoplasms, creatine, androgen antagonists, combined modality therapy, double-blind method, body composition, dietary supplements, aged, middle aged, male, muscle strength, resistance training
8 autores
- Ciaran M. Fairman🇦🇺 · autor de correspondenciaEdith Cowan University
- Kristina L. Kendall🇦🇺Edith Cowan University
- Robert Usher Newton🇦🇺Edith Cowan University; The University of Queensland
- Nicolas H. Hart🇦🇺Edith Cowan University; The University of Notre Dame Australia
- Dennis R. Taaffe🇦🇺Edith Cowan University; The University of Queensland
- Raphael Chee🇦🇺Edith Cowan University; GenesisCare
- Colin Tang🇦🇺Sir Charles Gairdner Hospital
- Daniel Abido Galvao🇦🇺Edith Cowan University; The University of Queensland
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Creatine supplementation has consistently been demonstrated to augment adaptations in body composition, muscle strength and physical function in a variety of apparently healthy older adults and clinical populations. The effects of creatine supplementation and resistance training in individuals with cancer have yet to be investigated. This study aims to examine the effects of creatine supplementation in conjunction with resistance training on body composition, muscle strength and physical function in prostate cancer patients undergoing androgen deprivation therapy.
Methods and analysis
This is a randomised, double-blind, placebo-controlled trial designed to examine the effects of creatine supplementation in addition to resistance training in patients with prostate cancer receiving androgen deprivation therapy. Both supplement and placebo groups will receive a 12-week supervised exercise programme comprising resistance training undertaken three times per week. The primary endpoint (fat-free mass) and secondary endpoints (fat mass, per cent body fat, physical fitness, quality of life and blood biomarkers) will be assessed at baseline and immediately following the intervention.
Ethics and dissemination
The Human Research Ethics Committee of Edith Cowan University approved this study (ID: 22243 FAIRMAN). If the results of this trial demonstrate that creatine supplementation can augment beneficial adaptations of body composition, physical function and/or psychosocial outcomes to resistance training, this study will provide effect sizes that will inform the design of subsequent definitive randomised controlled trials. The results of this study will be published in peer-reviewed journals and presented at various national and international conferences.
Trial registration number
ACTRN12619000099123.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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