Calcium: magnesium intake ratio and colorectal carcinogenesis, results from the prostate, lung, colorectal, and ovarian cancer screening trial
Zhao J, Giri A, Zhu X, Shrubsole MJ, Jiang Y, Guo X, Ness R, Seidner DL, Giovannucci E, Edwards TL, Dai Q
British journal of cancer · 19 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Health and Human Services
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Gobierno
- NICHD NIH HHS
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCI NIH HHS
- Gobierno
- U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)
- Subvenciones
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12-HD043483); National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK-058404); U.S. Department of Health and Human Services (U01CA182364); National Institutes of Health (6u01ca182364-03); National Cancer Institute (U01 CA182364)
Según 9 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-09-22 · Br J Cancer · vol. 121 · número 9 · págs. 796–804
- Editorial
- Springer Nature
- Citado
- 28 citas · más que el 88% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Colorectal Cancer Screening and Detection · Parathyroid Disorders and Treatments
- Palabras clave
- Colorectal adenoma, Medicine, Calcium, Colorectal cancer, Adenoma, Internal medicine, Gastroenterology, Endocrinology, Oncology, Cancer
- MeSH
- humans, colorectal neoplasms, ovarian neoplasms, lung neoplasms, prostatic neoplasms, neoplasms, second primary, calcium, magnesium, incidence, aged, middle aged, female, male, early detection of cancer, carcinogenesis
11 autores
- Jing Zhao🇺🇸Vanderbilt University Medical Center
- Ayush Giri🇺🇸Vanderbilt University Medical Center
- Xiangzhu Zhu🇺🇸Vanderbilt University Medical Center
- Martha J. Shrubsole🇺🇸Vanderbilt University Medical Center
- Yixing Jiang🇺🇸University of Maryland, Baltimore
- Xingyi Guo🇺🇸Vanderbilt University Medical Center
- Reid M. Ness🇺🇸Vanderbilt University Medical Center
- Douglas L. Seidner🇺🇸Vanderbilt University Medical Center
- Edward L. Giovannucci🇺🇸Harvard University
- Todd L. Edwards🇺🇸Vanderbilt University Medical Center
- Qi Dai🇺🇸 · autor de correspondenciaVanderbilt University; Vanderbilt University Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
We aimed to evaluate the associations between calcium and various stages of colorectal carcinogenesis and whether these associations are modified by the calcium to magnesium (Ca:Mg) ratio.
Methods
We tested our hypotheses in the prostate lung, colorectal and ovarian cancer screening trial.
Results
Calcium intake did not show a dose-response association with incident adenoma of any size/stage (P-trend = 0.17), but followed an inverse trend when restricted to synchronous/advanced adenoma cases (P-trend = 0.05). This inverse trend was mainly in participants with Ca:Mg ratios between 1.7 and 2.5 (P-trend = 0.05). No significant associations were observed for metachronous adenoma. Calcium intake was inversely associated with CRC (P-trend = 0.03); the association was primarily present for distal CRC (P-trend = 0.01). The inverse association between calcium and distal CRC was further modified by the Ca:Mg ratio (P-interaction trend = 0.04). No associations for calcium were found in the Ca:Mg ratio above 2.5 or below 1.7.
Conclusion
Higher calcium intake may be related to reduced risks of incident advanced and/or synchronous adenoma and incident distal CRC among subjects with Ca:Mg intake ratios between 1.7 and 2.5.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.