Whole Grain Brown Rice Extrudate Ameliorates the Symptoms of Diabetes by Activating the IRS1/PI3K/AKT Insulin Pathway in db/db Mice
Gao Y, Zhang M, Zhang R, You L, Li T, Liu RH
Journal of agricultural and food chemistry · 42 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministry of Education of the People's Republic of China
- Gobierno
- Natural Science Foundation of Guangdong Province
- Gobierno
- State Administration of Foreign Experts Affairs
- Gobierno
- Ministry of Education of the People's Republic of China
- Gobierno
- Science and Technology Planning Project of Nansha, Guangzhou
- Subvenciones
- State Administration of Foreign Experts Affairs (B17018); Natural Science Foundation of Guangdong Province (2016A030312001); Ministry of Education of the People's Republic of China (B17018)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2019-09-24 · J Agric Food Chem · vol. 67 · número 42 · págs. 11657–11664
- Editorial
- American Chemical Society
- Citado
- 82 citas · más que el 96% de estudios similares · 6.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- De pago
- Áreas de investigación
- GABA and Rice Research · Diet, Metabolism, and Disease · Food composition and properties
- Palabras clave
- Internal medicine, Insulin resistance, Endocrinology, IRS1, Insulin receptor, Protein kinase B, Glycogen synthase, Insulin, Glycogen, PI3K/AKT/mTOR pathway, Insulin receptor substrate, GSK-3, Biology, Phosphorylation, Signal transduction, Medicine, Biochemistry
- MeSH
- animals, mice, inbred c57bl, humans, mice, mice, obese, diabetes mellitus, type 2, insulin, blood glucose, glucose tolerance test, signal transduction, male, proto-oncogene proteins c-akt, insulin receptor substrate proteins, phosphatidylinositol 3-kinase, oryza, glycogen synthase kinase 3 beta
6 autores
- Yue Gao🇨🇳South China University of Technology
- Mingwei Zhang🇨🇳Guangdong Academy of Agricultural Sciences; Ministry of Agriculture and Rural Affairs
- Ruifen Zhang🇨🇳Guangdong Academy of Agricultural Sciences; Ministry of Agriculture and Rural Affairs
- Lijun You🇨🇳South China University of Technology
- Tong Li🇺🇸Cornell University
- Rui Hai Liu🇺🇸 · autor de correspondenciaCornell University
Resumen
El texto original del estudio, en el idioma en que se publicó.
The therapeutic benefits of whole grains on diabetes mellitus have been continuously confirmed by in-depth research. To date, limited studies have investigated the effect of extruded products of whole grains on the insulin signaling pathway in vivo. This study investigated the effects of oral consumption of whole grain extrudate, including 97% brown rice and 3% defatted rice bran (w/w, BRD), on glucose metabolism and the hepatic insulin signaling pathway in C57BL/KsJ-db/db mice. BRD treatment induced a remarkable reduction in blood glucose. Moreover, glucose intolerance and insulin resistance were ameliorated in the BRD-treated group compared with those in the db/db control group. BRD also increased the hepatic glycogen content by reducing the expression and increasing the phosphorylation of glycogen synthase kinase 3β (GSK3β). The activities of glucose-6-phosphatase and phosphoenolpyruvate carboxylase and their respective mRNA expression levels in the liver were simultaneously decreased in the BRD-treated group. BRD also significantly upregulated the expression of phosphatidylinositol 3-kinase (PI3K) and increased the phosphorylation of insulin receptor substrate 1 (IRS1) and protein kinase B (AKT). These results indicate that BRD exhibits antidiabetic potential by activating the IRS1/PI3K/AKT signaling pathway, further regulating the expression of the FOXO1 gene and p-GSK3β protein, thus inhibiting hepatic gluconeogenesis, increasing hepatic glycogen storage, and improving insulin resistance. Therefore, BRD could be used as a functional ingredient to alleviate the symptoms of hyperglycemia.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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