Transcranial Photobiomodulation Improves Cognitive Performance in Young Healthy Adults: A Systematic Review and Meta-Analysis
Salehpour F, Majdi A, Pazhuhi M, Ghasemi F, Khademi M, Pashazadeh F, Hamblin MR, Cassano P
Photobiomodulation, photomedicine, and laser surgery · 33 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Allergy and Infectious Diseases
- Gobierno
- NIAID NIH HHS
- Subvenciones
- National Institute of Allergy and Infectious Diseases (R21 AI121700); National Institute of Allergy and Infectious Diseases (R01AI050875)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2019-09-24 · Photobiomodul Photomed Laser Surg · vol. 37 · número 10 · págs. 635–643
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 52 citas · más que el 58% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Transcranial Magnetic Stimulation Studies · Photodynamic Therapy Research Studies
- Palabras clave
- transcranial photobiomodulation, cognitive performance, healthy young adults, attention, memory, cognitive enhancement, non-invasive brain stimulation, publication bias
- MeSH
- skull, brain, humans, retrospective studies, cohort studies, cognition, reference values, female, male, young adult, quality improvement, healthy volunteers, low-level light therapy
8 autores
- Farzad Salehpour🇮🇷 · autor de correspondenciaTabriz University of Medical Sciences
- Alireza Majdi🇮🇷Tabriz University of Medical Sciences
- Mahdiyeh Pazhuhi🇮🇷University of Tabriz
- Faranak Ghasemi🇮🇷Tabriz University of Medical Sciences
- Mahsa Khademi🇮🇷Tabriz University of Medical Sciences
- Fariba Pashazadeh🇮🇷Tabriz University of Medical Sciences
- Michael R. Hamblin🇺🇸Harvard University; Massachusetts General Hospital; Harvard–MIT Division of Health Sciences and Technology
- Paolo Cassano🇺🇸 · autor de correspondenciaHarvard University; Massachusetts General Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: Transcranial photobiomodulation (t-PBM) is a noninvasive modality that may improve cognitive function in both healthy and diseased subjects. Objective: This systematic review and meta-analysis addresses the question of whether t-PBM improves cognitive function in healthy adults. Methods: We searched MEDLINE using PubMed, EMBASE, SCOPUS, Web of Science, and Cochrane Library up to March 2019. We also searched ProQuest and Google Scholar databases for unpublished material. The search was limited to articles on the procognitive effects of t-PBM in healthy adults. The initial search resulted in 871 studies, of which nine publications met our criteria for inclusion and exclusion. Seven studies were performed on young, healthy subjects (17-35 years), and two studies were conducted on older (≥49 years), normal subjects. A meta-analysis was performed on six full-text publications whose subjects were young adults. Results: t-PBM administration improved cognition-related outcomes by an 0.833 standardized mean difference (SMD; 95% confidence interval (CI): 0.458-1.209, 14 comparisons) in young, healthy participants. Funnel plotting revealed asymmetry, which was validated using Egger's (p = 0.030) and Begg's regression (p = 0.006) tests. However after reanalysis, this asymmetry disappeared in the attention subgroup, but not in the memory subgroup. The trim-and-fill analysis indicated two studies were lacking required data. Thus, the effect size was adjusted from an SMD of 0.761 (95% CI: 0.573-0.949) to 0.949 (0.779-1.120). The overall quality score of the studies was modest. Conclusions: We demonstrated a significant, beneficial effect of t-PBM on cognitive performance of young, healthy individuals; however, the heterogeneity of the data was high. This could be due to the modest quality or to the low number of included studies, or to the differences between the various subdomains assessed. These shortcomings should be meticulously addressed before concluding that t-PBM is a cognitive-enhancing intervention in healthy individuals.
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