The role of vitamin D in increasing circulating T regulatory cell numbers and modulating T regulatory cell phenotypes in patients with inflammatory disease or in healthy volunteers: A systematic review
Fisher SA, Rahimzadeh M, Brierley C, Gration B, Doree C, Kimber CE, Plaza Cajide A, Lamikanra AA, Roberts DJ
PloS one · 118 citas
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Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- NHS Blood and Transplant
- Gobierno
- National Institute for Health and Care Research
- Gobierno
- National Institute for Health Research (NIHR)
- Subvenciones
- NHS Blood and Transplant (WP-15-11)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-09-24 · PLoS One · vol. 14 · número 9 · pág. e0222313
- Editorial
- Public Library of Science
- Citado
- 162 citas · más que el 86% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 58 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- T-cell and B-cell Immunology · Vitamin D Research Studies · Psoriasis: Treatment and Pathogenesis
- Palabras clave
- vitamin D, regulatory T cells, Treg phenotype, autoimmune disease, inflammatory diseases, vitamin A, nicotinic acid, short-chain fatty acids, vitamin D supplementation, immunomodulation
- MeSH
- humans, autoimmune diseases, inflammation, vitamin d, lymphocyte count, t-lymphocytes, regulatory
9 autores
- Sheila A. Fisher🇬🇧University of Oxford
- Mana Rahimzadeh🇬🇧John Radcliffe Hospital; University of Oxford
- Charlotte K. Brierley🇬🇧Churchill Hospital
- Betty Gration🇬🇧St Thomas' Hospital; Guy's and St Thomas' NHS Foundation Trust
- Carolyn J. Doree🇬🇧University of Oxford
- Catherine Kimber🇬🇧University of Oxford
- Alicia Plaza Cajide🇬🇧University of Oxford
- Abigail Lamikanra🇬🇧University of Oxford
- David J. Roberts🇬🇧 · autor de correspondenciaChurchill Hospital; University of Oxford; Oxford University Hospitals NHS Trust
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The evidence for vitamin D and other agents that experimentally modulate T regulatory cells (Tregs) for the treatment of patients with autoimmune or allergic diseases has not been established.
Objective
We have undertaken a systematic review of randomised controlled trials to assess the efficacy of vitamin D, vitamin A, niacin and short-chain fatty acids in enhancing absolute Treg numbers and phenotypes in patients with inflammatory or autoimmune disease.
Methods
This systematic review was conducted using a predefined protocol (PROSPERO International prospective register of systematic reviews, ID = CRD42016048648/ CRD42016048646). Randomised controlled trials of patients with inflammatory or autoimmune disease or healthy participants which compared either oral vitamin D or vitamin A or short-chain fatty acids with control or placebo and measured the absolute concentration of proportion of Tregs were eligible for inclusion. Searches of electronic databases (CENTRAL, MEDLINE, EMBASE, CINAHL, PUBMED and Web of Science) identified eight eligible independent trials (seven autoimmune disease trials, one trial of healthy subjects). Data were extracted by two reviewers and the risk of study bias was assessed using Cochrane Collaboration methodology.
Results
Planned meta-analysis was not possible due to the heterogeneous nature of the studies. Nevertheless, in five trials of autoimmune disorders which measured the proportion of Tregs, a higher proportion was observed in the vitamin D group compared to controls at 12 months in all but one trial. In the trial of healthy subjects, a significant difference was reported, with a higher percentage of Tregs observed in the vitamin D group (at 12 weeks, mean 6.4% (SD 0.8%) (vitamin D) vs 5.5% (1.0%) (placebo). There were no trials to assess the efficacy of vitamin A, niacin and short-chain fatty acids in enhancing absolute Treg numbers.
Conclusions
Vitamin D supplementation may increase Treg/CD3 ratios in both healthy individuals and patients with autoimmune disorders and may increase Treg function. There remains a need for further suitably powered clinical studies aimed at enhancing Treg numbers and/or function.
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