25-Hydroxyvitamin D and Total Cancer Incidence and Mortality: A Meta-Analysis of Prospective Cohort Studies
Han J, Guo X, Yu X, Liu S, Cui X, Zhang B, Liang H
Nutrients · 60 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Key Research and Development Project of Shandong Province
- Subvenciones
- National Natural Science Foundation of China (81872605); National Natural Science Foundation of China (81573137)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-09-26 · Nutrients · vol. 11 · número 10 · pág. 2295
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 80 citas · más que el 88% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 64 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Vitamin C and Antioxidants Research
- Palabras clave
- Medicine, Relative risk, Prospective cohort study, Internal medicine, Meta-analysis, Incidence (geometry), Confidence interval, Cancer, Cohort study
- MeSH
- humans, neoplasms, vitamin d deficiency, vitamin d, incidence, risk factors, prospective studies
7 autores
- Jianmin Han🇨🇳Qingdao University
- Xiaofei Guo🇨🇳Qingdao University
- Xiao Yu🇨🇳Qingdao University
- Shuang Liu🇨🇳Qingdao University
- Xinyue Cui🇨🇳Qingdao University
- Bo Zhang🇨🇳Qingdao University
- Hui Liang🇨🇳 · autor de correspondenciaQingdao University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Epidemiological studies have suggested inconclusive associations between 25-hydroxyvitamin D and total cancer incidence and mortality. The aim of this study was to quantitatively assess these associations by combining results from prospective cohort studies. A systematic literature search was implemented in PubMed and Scopus databases in April 2019. Comparing the highest with the lowest categories, the multivariate-adjusted relative risks (RRs) and the corresponding 95% confidence intervals (CIs) were pooled using a random-effects model. A trend estimation was performed using a two-stage, dose-response, meta-analysis method. Twenty-three independent prospective studies were included for data synthesis. Eight studies investigated the association between 25-hydroxyvitamin D and the risk of cancer incidence (7511 events and 70,018 participants), and the summary estimate showed that 25-hydroxyvitamin D is marginally associated with cancer risk (Summary RR = 0.86; 95% CI: 0.73, 1.02; I2 = 70.8%; p = 0.001). Sixteen studies investigated the association between 25-hydroxyvitamin D and the risk of cancer mortality (8729 events and 101,794 participants), and a higher 25-hydroxyvitamin D concentration was inversely associated with the risk of cancer mortality (Summary RR = 0.81; 95% CI: 0.71, 0.93; I2 = 48.8%, p = 0.012). Dose-response analysis indicated that the risk of cancer incidence was reduced by 7% (RRs = 0.93; 95% CI: 0.91, 0.96), and the risk of cancer mortality was reduced by 2% (RRs = 0.98; 95% CI: 0.97, 0.99), with each 20 nmol/L increment of 25-hydroxyvitamin D concentration. This meta-analysis provides evidence that a higher 25-hydroxyvitamin D concentration is associated with a lower cancer incidence and cancer mortality.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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